2012 Fiscal Year Final Research Report

Pathogenesis of influenza virus-associated encephalopathy of childhood induced in animal model

Research Project

Project/Area Number	23658250
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	UMEMURA Takashi 北海道大学, 大学院・獣医学研究科, 特任教授 (00151936)
Project Period (FY)	2011 – 2012
Keywords	インフルエンザ性脳症 / リポ多糖体 / 小児 / 血液脳関門 / 高サイトカイン血症
Research Abstract	In the present study, I demonstrated that influenza virus (IFV) infection to the lungs of suckling mice enhanced encephalopathy and hypercytokinemia due to lipopolysaccharide (LPS) inoculation, and brain pathology, hypercytokinemia and absence of IFV in the brain of the animal model treated with IFV and LPS were similar to IFV-associated encephalopathy of childhood. Furthermore, it was suggested from the present study that the apoptosis of vascular endothelial cell and astrocytes causing increased permeability of blood brain barrier might be the major contributing factor forIFV-associated encephalopathy of childhood.

(3 results)