2012 Fiscal Year Final Research Report
Development and clinical applications of procedures for regulating the exosome formation based on the genetic traits of canine erythroid cells.
| Project/Area Number |
23658257
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SATO Kota 北海道大学, 大学院・獣医学研究科, 准教授 (50283974)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Mutsumi 北海道大学, 大学院・獣医学研究科, 教授 (00183179)
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| Project Period (FY) |
2011 – 2012
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| Keywords | エキソソーム / 赤血球 / ラフト / 遺伝的形質 |
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| Research Abstract |
The HK phenotype in dog erythrocytes is suggested to be caused by disorders in lipid raft and exosome formations. However, the molecular basis of the disorders remains unknown. To clarify the mechanisms for regulating the exosome formation, we compared the protein contents of red cells, reticulocytes and exosomes from HK and normal dogs. Resultant candidate protein “Stomatin” was not a cause of HK phenotype. The genome-wide association study revealed that the causative gene located in canine chromosome 12 would be associated with the exosome and raft disorders.
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Research Products
(12 results)
