2012 Fiscal Year Final Research Report
A concept on innovative treatments to epitheliotropiclymphoma targeting to molecules associated with segregation of lymphocytes from lesional skin
| Project/Area Number |
23658261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Sanae 岐阜大学, 応用生物科学部, 助教 (20588917)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 内科 |
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| Research Abstract |
The present results indicated that the skin-homing property of CCR4, CCR7, CCR10 and CXCR3 may contribute to the development of specific accumulation of neoplastic lymphocytes in the skin, which is the new concept of involvement of active skin migration of cytotoxic T-cells from blood circulation of cECL. These chemokine receptors could be therapeutic targets by regulating the migration of neoplastic lymphocytes in cECL.
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[Journal Article] Gene transcription analysis in lesional skin of canine epitheliotropic cutaneous lymphoma using quantitative real-time RT-PCR2011
Author(s)
Chimura, N., Kondo, N., Shibata, S., Kimura, T., Mori, T., Hoshino, Y., Murayama, N., Nagata, M., Ide, K., Nishifuji, K., Kamishina, H., Maeda, S
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Journal Title
Vet. Immunol. Immunopathol
Volume: 144
Pages: 329-36
DOI
Peer Reviewed
