Development ofthe safely sterilization agent for prevention of secondary prion infection through medical instruments

2012 Fiscal Year Final Research Report

• Project/Area Number: 23658277
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Boundary agriculture
• Research Institution: Kyushu University
• Principal Investigator: TSUTSUMI Yuji 九州大学, 大学院・農学研究院, 教授 (30236921)
• Co-Investigator(Kenkyū-buntansha): MOHRI Shiro 独立行政法人農業, 食品産業技術総合研究機構・動物衛生研究所, プリオン病研究センター・センター長 (40117271)
• Project Period (FY): 2011 – 2012
• Keywords: プリオン病 / マンガンペルオキシダーゼ / 感染性除去 / 二次感染防除 / 医療器具洗浄剤

Research Abstract

It has been well-known that abnormal prion protein is highly resistant against standard sterilization or chemical cleaning, and that high temperature-pressure or strong chemical treatment are required to sterilize its infectivity, however, these severe treatments are not applicable to some precision medical instrument, such as endoscopes. In this study, we investigated a capability of the enzyme, manganese peroxidase, to degrade and sterilize prion infectivity and tried to develop a new safely sterilization agent for precision medical instruments.