2012 Fiscal Year Final Research Report
Organocatalytic Deprotonation Reaction Using Onium Amide
| Project/Area Number |
23659001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
KONDO Yoshinori 東北大学, 大学院・薬学研究科, 教授 (90162122)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 有機反応学 / 分子活性化 / 分子変換 / 有機触媒 |
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| Research Abstract |
Organocatalytic process has been regarded to be attractive from viewpoints of selectivity, safety, and sustainability, and the development of organocatalytic processes for deprotonative functionalization of aromatics and heteroaromatics is considered to be one of highly challenging subjects in organic synthesis. We have been working on organocatalytic transformation of aromatic and heteroaromatic compounds, and we developed a simple catalytic deprotonative functionalization of heteroaromatic ring under metal-free mild conditions using onium amides, generated in situ from the combination of aminosilanes and onium fluorides, as bases.
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Research Products
(11 results)
