2012 Fiscal Year Final Research Report
Study of Environmentally Benign One-Pot Syntheses of Heterocyclic Key Intermediates for Drug
| Project/Area Number |
23659010
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
ITOH Akichika 岐阜薬科大学, 薬学部, 教授 (10203126)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 光酸素酸化反応 / ワンポット / ハロゲン / 触媒 / 複素環 / フェナシルハライド / スチレン |
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| Research Abstract |
We studied one-pot syntheses of imidazoles, thiazoles and oxazoles from styrenes; however, we could not obtain the corresponding heterocyclic compounds. Since considerable quantity of intermediates phenacyl halides were detected in the reaction mixture, deactivation of coupling reagents, for example thioamides, is thought to be the reason for these results. We believe that further optimization of reaction conditions for activation of coupling reagent develops one-pot synthesis of these heterocyclic compounds.
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