2012 Fiscal Year Final Research Report
Encapsulation of a poorly water-soluble drug with large molecular size into organic nanotube
| Project/Area Number |
23659017
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAMOTO Keiji 千葉大学, 大学院・薬学研究院, 教授 (50110341)
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| Co-Investigator(Kenkyū-buntansha) |
MORIBE Kunikazu 千葉大学, 大学院・薬学研究院, 准教授 (50266350)
HIGASHI Kenjirou 千葉大学, 大学院・薬学研究院, 助教 (40451760)
LIMWIKRANT Waree 千葉大学, 大学院・薬学研究院, 助教 (50595907)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 有機ナノチューブ / 難水溶性薬物 / 経口製剤 / 溶解性改善 / 固体分散体 / 非晶質 / 刺激応答性 / 放出制御 |
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| Research Abstract |
Hydrocortisone (HC) as a poorly water-soluble drug was encapsulated into organic nanotube (ONT), which was formed by self-assembly of N-{12-[(2-α,β-D-glucopyranosyl)carbamoyl]dodecanyl}-glycylglycylglycine acid. The solubility of ONT in acetone was determined as 0.015 mg/mL by solution state1H-NMR spectroscopy, confirming that ONT was poorly-soluble in acetone. Evaporation using acetone was performed to prepare ONTs loaded with HC. Powder X-ray diffraction pattern of evaporated sample with weight ratio of HC/ONT=3/7 showed a hallo pattern without remained peaks of crystalline HC. <13>^C-solid state NMR measurements demonstrated that HC peaks became broadened in a spectrum of evaporated sample, compared with those of HC crystal. These results indicated thatHC was encapsulated in ONT as amorphous state.
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