Involvement of lipid-metabolizing enzymes in stress response

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659033
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori 東京大学, 大学院・薬学系研究科, 教授 (00242206)
• Project Period (FY): 2011 – 2012
• Keywords: ASK1 / 脂質 / ストレス応答 / シグナル伝達 / 線虫 / 緑膿菌感染 / MAP キナーゼ

Research Abstract

To analyze ASK family-dependent stress signaling, we identified 55 candidate ASK activator candidates by a genome-wide RNAi screening in C. elegans. Those candidates were further analyzed in the context of neuronal differentiation, innate immunity and oxidative stress response. Finally, we identified gene X as an activator of ASK1 by comparing it with known p38signaling components.

Research Products

• [Journal Article] Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic s cell exhaustion (2013)
  • Author(s): Yamaguchi, K., Takeda, K., Kadowaki, H., Ueda, I., Namba, Y., Ouchi, Y. Nishitoh, H. and Ichijo, H
  • Journal Title: Biochim. Biophys. Acta Volume: 1830 Pages: 3656-3663
  • DOI: doi:10.1016/j.bbagen.2013.01.029
  • Peer Reviewed
• [Journal Article] Y. Apoptosis Signal-regulating Kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells (2013)
  • Author(s): Tasaki, T., Yamada, S., Guo, X., Tanimoto, A., Wang, K-T., Nabeshima, A., Kitada, S., Noguchi H., Kimura, S., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri
  • Journal Title: Am. J. Pathol Volume: 182 Pages: 597-609
  • DOI: doi:10.1016/j.ajpath.2012.10.008
  • Peer Reviewed
• [Journal Article] Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling (2013)
  • Author(s): Shiizaki, S., Naguro, I. and Ichijo, H
  • Journal Title: Adv. Biol. Regul., (review article) Volume: 53 Pages: 135-144
  • DOI: doi:10.1016/j.jbior.2012.09.006
  • Peer Reviewed
• [Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury (2013)
  • Author(s): Katome, T., Namekata, K., Guo, X., Semba, K.,Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T
  • Journal Title: Cell Death Differ Volume: 20 Pages: 270-280
  • DOI: doi:10.1038/cdd.2012.122
  • Peer Reviewed
• [Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney (2012)
  • Author(s): Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H
  • Journal Title: Nat. Commun. Volume: 3 Pages: 1285
  • DOI: doi:10.1038/ncomms2283
  • Peer Reviewed
• [Journal Article] Apoptosis signal- regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer (2012)
  • Author(s): Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda1, S. and Koike, K
  • Journal Title: Cancer Sci Volume: 103 Pages: 2181-2185
  • Peer Reviewed
• [Journal Article] Thekelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5 (2012)
  • Author(s): Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H
  • Journal Title: Mol. Cell Volume: 48 Pages: 692-704
  • DOI: doi:10.1016/j.molcel.2012.09.018
  • Peer Reviewed
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss- induced cleavage of PGAM5 (2012)
  • Author(s): Sekine,S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H
  • Journal Title: J. Biol. Chem Volume: 287 Pages: 34635-34645
  • DOI: doi:10.1074/jbc.M112.357509
  • Peer Reviewed
• [Journal Article] Therapeutic targets in the ASK1- dependent stress signalling pathways (2012)
  • Author(s): Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H
  • Journal Title: Proc. Jpn. Acad. Ser. B: Phys. Biol. Sci.,(review article) Volume: 88 Pages: 434-453
  • DOI: doi:10.2183/pjab.88.434
  • Peer Reviewed
• [Journal Article] The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses (2012)
  • Author(s): Kanamaru, Y., Sekine S., Ichijo, H. and Takeda, K
  • Journal Title: J. Signal Transduc. (review article) Volume: 2012 Pages: 12
  • DOI: doi:10.1155/2012/931215
  • Peer Reviewed
• [Journal Article] ASK1 promotes apoptosis of normal and malignant plasma cells (2012)
  • Author(s): Lin, F.R., Huang, S.Y., Hung, K.H., Su, S.T., Chung, C.H., Matsuzawa, A., Hsiao, M., Ichijo, H. and Lin, K.I
  • Journal Title: Blood Volume: 120 Pages: 1039-1047
  • DOI: doi:10.1182/blood-2011-12-399808
  • Peer Reviewed
• [Journal Article] OxidativeStress-Induced Diseases via the ASK1Signaling Pathway (2012)
  • Author(s): Soga, M., Matsuzawa, A., Ichijo, H
  • Journal Title: Int. J. Cell Biol., (review article) Volume: 2012 Pages: 439587
  • DOI: doi:10.1155/2012/439587.
  • Peer Reviewed
• [Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants (2012)
  • Author(s): Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H
  • Journal Title: Ann. Neurol Volume: 72 Pages: 739-749
  • DOI: doi:10.1002/ana.23668
  • Peer Reviewed
• [Journal Article] S.H. Novel mechanism of angiotensin II-induced cardiacinjury in hypertensive rats: the critical role of ASK1 (2012)
  • Author(s): Nako, H., Kataoka, K., Koibuchi, N., Dong, Y.F., Toyama, K., Yamamoto, E., Yasuda, O., Ichijo, H., Ogawa, H. and Mitsuyama
  • Journal Title: Hypertens. Res Volume: 35 Pages: 194-200
  • DOI: doi:10.1038/hr.2011.175
  • Peer Reviewed
• [Journal Article] Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster (2012)
  • Author(s): Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K
  • Journal Title: PloS ONE Volume: 7 Pages: e30265
  • DOI: doi:10.1371/journal.pone.0030265
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation (2012)
  • Author(s): Lee, K.W., Zhao, X., Im, J.Y., Grosso, H., Jang, W.H., Chan, T.W., Sonsalla, P.K., German, D.C., Ichijo, H., Junn, E., and Mouradian, M.M
  • Journal Title: PloS ONE Volume: 7 Pages: e29935
  • DOI: doi:10.1371/journal.pone.0029935
  • Peer Reviewed
• [Journal Article] J. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway (2012)
  • Author(s): Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K. and Tschopp
  • Journal Title: Cell Death & Disease Volume: 3 Pages: e261
  • DOI: doi:10.1038/cddis.2011.132
  • Peer Reviewed
• [Journal Article] Deletion of apoptosis signal regulating kinase-1 prevents ventilatorinduced lung injury in mice (2011)
  • Author(s): Makena, P.S., Gorantla, V.K., Ghosh, M.C., Bezawada, L., Kandasamy, K., Balazs, L., Luellen, C.L., Thompson, K.E., Parthasarathi, K., Ichijo, H., Waters, C.M. and Sinclair, S.E
  • Journal Title: Am. J. Respir. Cell Mol. Biol. Volume: 46 Pages: 461-469
  • DOI: doi:10.1165/rcmb.2011-0234OC
  • Peer Reviewed
• [Journal Article] HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6 (2011)
  • Author(s): Dosal, RG., Horan, KA., Rahbek, SH., Ichijo, H., Chen, ZJ., Mieyal, JJ., Hartmann, R., Paludan, SR.
  • Journal Title: PLoS Pathogens Volume: 7 Pages: e1002250
  • DOI: doi/10.1371/journal.ppat.1002250
  • Peer Reviewed
• [Journal Article] Y. Apoptosis Signal-Regulating Kinase1 Deficiency Accelerates Hyperlipidemia- Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis (2011)
  • Author(s): Yamada, S., Ding, Y., Tanimoto, A., Wang, K.Y., Guo, X., Li, Z., Tasaki, T., Nabesima, A., Murata, Y., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri
  • Journal Title: Arterioscler. Thromb. Vasc. Biol Volume: 31 Pages: 1555-1564
  • DOI: doi:10.1161/ATVBAHA.111.227140
  • Peer Reviewed
• [Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors (2011)
  • Author(s): Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
  • Journal Title: J. Cell Sci Volume: 124 Pages: 3006-3016
  • DOI: doi:10.1242/jcs.085902
  • Peer Reviewed
• [Journal Article] S. Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress- activated MAPK (2011)
  • Author(s): Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., Yoshida, H., Koike, K. Ichijo, H. and Maeda
  • Journal Title: Hepatology Volume: 54 Pages: 185-195
  • DOI: doi:10.1002/hep.24357
  • Peer Reviewed
• [Presentation] Y. Redox control of cell death (2012)
  • Author(s): Ichijo, H., Sekine
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 20121214-16
• [Presentation] ASK Family Kinases in Stress Response and Disease (2012)
  • Author(s): Ichijo, H
  • Organizer: The 4th Takeda Science Foundation Symposium on PharmaSciences "On the Frontiers of Chemical Biology"
  • Place of Presentation: 東京
  • Year and Date: 20121203-04
• [Presentation] SOD1 as a molecular switch to initiate the homeostatic ER stress response (2012)
  • Author(s): Ichijo, H.
  • Organizer: The 2nd International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling"
  • Place of Presentation: 東京
  • Year and Date: 20121029-30
• [Presentation] SOD1 as a molecular switch to initiate homeostatic ER stress response under conditions of zinc deficiency (2012)
  • Author(s): Ichijo, H.
  • Organizer: 第33回内藤コ ンファレンス
  • Place of Presentation: 札幌
  • Year and Date: 20120626-29
• [Presentation] 亜鉛枯渇時に働く小胞体ストレス誘導スイッチとしてのSOD1の新規機能 (2012)
  • Author(s): 一條秀憲、本間謙吾
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 20120328-31
• [Presentation] SOD1 as a molecular switch to initiate the homeostatic ER stress response under conditions of zinc deficiency (2012)
  • Author(s): Homma, K., Yamaguchi, N., Fujisawa, T., Nishitoh, H., Ichijo, H.
  • Organizer: The International Society for Zinc Biology (ISZB) 2012 Conference
  • Place of Presentation: Novotel, St.Kilda Australia.
  • Year and Date: 20120115-19
• [Presentation] Stress signaling in cell death, infiammation and disease (2011)
  • Author(s): Ichijo, H.
  • Organizer: The 23th Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 20111006-07
• [Presentation] 亜鉛枯渇によるSOD1-Derlin-1結合を介した小胞体ストレスの生理的意義 (2011)
  • Author(s): 一條秀憲、本間謙吾、藤澤貴央、西頭英起
  • Organizer: 第22回日本微量元素学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20110701-02
• [Presentation] ALS発症のメカニズム
  • Author(s): 一條秀憲
  • Organizer: 第5回東京アンチエイジングアカデミー
  • Place of Presentation: 東京