2012 Fiscal Year Final Research Report
High Energy Materials for Cancer Drugs: A Novel Mechanism of Action
| Project/Area Number |
23659052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
SHLBATA Norio 名古屋工業大学, 工学研究科, 教授 (40293302)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 医薬品化学 |
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| Research Abstract |
Designed and synthesis of a novel anti-cancer agent, trifluoroethoxyphthalocyanine-aminotetrazole conjugate (TFEO-Pc-AT) is described. The target compound was synthesized nicely by the use of copper-catalyzed Click-reaction of 1-(2-azidoethyl)-5-aminotetrazole and phthalocyanine containing terminal alkyne as a key step. TFEO-Pc-AT showed excellent photodynamic activities against B16-F10 murine melanoma upon illumination with a 660 nm laser, while no cytotoxicity of TFEO-Pc-AT was observed without illumination.
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