2012 Fiscal Year Final Research Report
New Strategy for Controlling Activity of Bioactive Compounds by Introduction of Catenane or Rotaxane Structure
| Project/Area Number |
23659058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Naoki 名古屋市立大学, 大学院・薬学研究科, 准教授 (40347422)
KATO Nobuki 名古屋市立大学, 大学院・薬学研究科, 助教 (50400221)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗ガン活性 / プロドラッグ / トポロジー |
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| Research Abstract |
This research project aims development of new methodology for controlling the activity of bioactive compound by introducing catenane or rotaxane structure that is removable under a certain condition. We have mainly deal with catenane structure. We examined construction of catenane between a macrocyclic model compoundand macrocyclic disulfide of which S-S bond is cleavable under reductive condition. We have succeeded in the improvement of macrocyclic disulfide structure for efficient catenane synthesis.
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[Journal Article] Effect of Helical Conformation and Side-Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition2013
Author(s)
Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
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Journal Title
J. Med. Chem
Volume: 56(4)
Pages: 1443-1454
DOI
Peer Reviewed
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