2012 Fiscal Year Final Research Report
The role of SmgGDS in the pleiotropic effects by statins
| Project/Area Number |
23659071
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高等教育開発推進センター, 准教授 (80436120)
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| Project Period (FY) |
2011 – 2012
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| Keywords | シグナル伝達 / スタチン / 低分子量G蛋白 |
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| Research Abstract |
We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
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Research Products
(26 results)
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[Journal Article] Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registry study of the Japanese Coronary Spasm Association-2013
Author(s)
Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H.
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Journal Title
Eur Heart J
Volume: 34
Pages: 258-267
DOI
Peer Reviewed
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[Journal Article] Plasma cyclophilin A is a novel biomarker for coronary artery disease2013
Author(s)
Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H.
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Journal Title
Circ J
Volume: 77
Pages: 447-455
DOI
Peer Reviewed
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[Journal Article] Long-term treatment with nifedipine suppresses coronary hyperconstrcting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: Possible involvement of Rho-kinase pathway-2012
Author(s)
Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H.
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Journal Title
Eur Heart J
Volume: 33
Pages: 791-799
DOI
Peer Reviewed
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