2012 Fiscal Year Final Research Report
Understanding of molecular mechanism and development of prediction system of drug- induced hepatotoxicity, focusing on the inflammation-associated nuclear receptors and cell-cell interactions.
| Project/Area Number |
23659072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 医薬品情報 / 安全性学 |
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| Research Abstract |
In this study, we have investigated the influences of treatment with the activators of inflammation-associated nuclear receptors on the gene expression profile of inflammation-related genes in human model macrophages and rat Kupffer cells. The results suggest that the activation of either PXR, CAR, LXRα, PPAR or PPARγ elicits the changes in the gene expression of the several genes investigated, that the influence is dependent on the nuclear receptors, and that the changes are regulated at the transcriptional levels. These imply that not only parenchymal hepatocytes but non-parenchymal hepatocytes are targets for the drug- or xenobiotic-induced liver inflammation.
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