2012 Fiscal Year Final Research Report
Evaluation of pharmacokinetic using silkworm as an animal model
| Project/Area Number |
23659074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | カイコ / 薬物動態 / シトクローム P450 / 抗生物質 |
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| Research Abstract |
In this research, it is shown that cytochrome P450 is expressed in silkworm midgut and most of compounds, metabolized by cytochrome P450 in mammals, were also metabolized in silkworm midgut. The transgenic silkworm expressing human cytochrome P450 could metabolize the compound that was not metabolized in wild-type silkworm. These results further entrenched usefulness of silkworm as a model animal for drug discovery.
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Research Products
(13 results)
