2012 Fiscal Year Final Research Report
Novel strategy of drug therapy for inflammatory bowel diseases based on the combination of drug transport and intestinal immunology.
| Project/Area Number |
23659077
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDOH Akira 滋賀医科大学, 大学院・医学系研究科, 教授 (90252395)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 薬学 / 薬剤反応性 / 薬理学 / 薬物トランスポータ / 炎症性腸疾患 |
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| Research Abstract |
Expression of peptide transporter PEPT1 in the large intestine of inflammatory bowel disease (IBD) patients was specifically induced in the inflammatory region. Furthermore, this expression was suggested to be stimulated by intestine-specific transcription factor CDX2. Based on the literature and molecular design methods, eight kinds of amino acid derivatives of 5-aminosalicylic acid were synthesized, which can become the substrates for PEPT1. The interaction of PEPT1 with these amino acid derivatives of 5-aminosalicylic acid will be evaluated from the view points of in vitro and in vivo.
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[Journal Article] Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes. : Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes2013
Author(s)
Morita, S., Tsuda, T., Horikami, M., Teraoka, R., Kitagawa, S. and Terada, T.
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Journal Title
J. Lipid Res
Volume: 54
Pages: 54
DOI
Peer Reviewed
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[Journal Article] Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice2013
Author(s)
Aomatsu, T., Imaeda, H., Takahashi, K., Fujimoto, T., Kasumi, E., Ban, H., Bamba, S., Yoden, A., Tamai, H., Fujiyama, Y. and Andoh, A.
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Journal Title
Biochem. Nutr.
Volume: 52
Pages: 72-75
DOI
Peer Reviewed
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[Journal Article] Renal tubular secretion of varenicline by multidrug and toxin extrusion (MATE) transporters.2012
Author(s)
Kajiwara, M., Masuda, S., Watanabe, S., Terada, T., Katsura, T. and Inui, K.
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Journal Title
Drug Metab. Pharmacokinet.
Volume: 27(6)
Pages: 563-569
URL
Peer Reviewed
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[Journal Article] Enzymatic measurement of phosphatidylserine in cultured cells2012
Author(s)
Morita, S., Shirakawa, S., Kobayashi, Y., Nakamura, K., Teraoka, R., Kitagawa, S. and Terada, T.
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Journal Title
J. Lipid Res.
Volume: 53(2)
Pages: 325-330
DOI
Peer Reviewed
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[Journal Article] The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range2012
Author(s)
Bamba, S., Andoh, A., Ban, H., Imaeda, H., Aomatsu, T., Kobori, A., Mochizuki, Y., Shioya, M., Nishimura, T., Inatomi, O., Sasaki, M., Saitoh, Y., Tsujikawa, T., Araki, Y. and Fujiyama, Y.
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Journal Title
Dig. Dis. Sci
Volume: 57(2)
Pages: 327-334
DOI
Peer Reviewed
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[Journal Article] Effects of phosphatidylethanolamineN-methyltransferase on phospholipid composition, microvillus formation and bile salt resistance in LLC-PK1 cells2011
Author(s)
Morita, S., Ikeda, N., Horikami, M., Soda, K., Ishihara, K., Teraoka, R., Terada, T. and Kitagawa, S
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Journal Title
FEBS J.
Volume: 278(24)
Pages: 4768-4781
DOI
Peer Reviewed
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[Journal Article] Human NPC1L1 expression is positively regulated by PPARα2011
Author(s)
Iwayanagi, Y., Takada, T., Tomura, F., Yamanashi, Y., Terada, T., Inui, K. and Suzuki, H
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Journal Title
Pharm. Res.
Volume: 28(2)
Pages: 405-412
DOI
Peer Reviewed
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[Journal Article] Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis2011
Author(s)
Imaeda, H., Andoh, A., Aomatsu, T., Uchiyama, K., Bamba, S., Tsujikawa, T., Naito, Y. and Fujiyama, Y.
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Journal Title
Int. J. Mol. Med.
Volume: 28(4)
Pages: 573-578
DOI
Peer Reviewed
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