A physiological role of a novel gaseous mediator hydrogen sulfide

2013 Fiscal Year Final Research Report

• Project/Area Number: 23659089
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: KIMURA Hideo 独立行政法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 部長 (30321889)
• Project Period (FY): 2011 – 2013
• Keywords: 硫化水素 / ポリサルファイド / Ｄ－システイン

Research Abstract

Hydrogen sulfide (H2S) is recognized as a physiological mediator, and its roles and therapeutic applications have been studied. In the present study we examined 1. the regulation of producing enzymes, especially focusing on their co-enzymes and co-factors, 2. the protection of the retina from intensive light-induced degeneration, 3. the idenfitication of H2S-sensitive molecules, 4. a role as an endothelium-derived relaxing factor, 5. the development of H2S imaging probes.

Research Products

• [Journal Article] Production and physiological effects of hydrogen sulfide (2014)
  • Author(s): Kimura, H.
  • Journal Title: Antioxid. Redox Signal Volume: 20 Pages: 783-793
  • DOI: 10.1089/ars.2013.5309
  • Peer Reviewed
• [Journal Article] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells (2013)
  • Author(s): Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N. and Kimura, H
  • Journal Title: Nat. Commun Volume: 4 Pages: 1366
  • DOI: 10.1038/ncomms2371,10.1038/ncomms2371
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide is produced by cystathionine □-lyase at the steady-state low intracellular Ca^<2>+ concentrations. Biochem. Biophys (2013)
  • Author(s): Mikami, Y., Shibuya, N., Ogasawara, Y. and Kimura, H
  • Journal Title: Res. Commun Volume: 431 Pages: 131-135
  • DOI: 10.1016/j.bbrc.2013.01.010
  • Peer Reviewed
• [Journal Article] Polysulfides are possible H2S-derived signaling molecules in rat brain (2013)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I, and Kimura, H
  • Journal Title: FASEB J Volume: 27 Pages: 2451-2457
  • DOI: 10.1096/fj.12-226415
  • Peer Reviewed
• [Journal Article] Production of hydrogen sulfide from D-cysteine and its therapeutic potential (2013)
  • Author(s): Shibuya, N., Kimura, H
  • Journal Title: Frontiers in Endocrinology Volume: 4 Pages: Article 87
  • DOI: 10.3389/fendo.2013.00087
  • Peer Reviewed
• [Journal Article] Nutritional essentiality of sulfur in health and disease (2013)
  • Author(s): Ingenbleek, Y., Kimura, H
  • Journal Title: Nutr Volume: Rev. 71 Pages: 413-432
  • DOI: 10.1111/nure.12050
  • Peer Reviewed
• [Journal Article] Physiological role of hydrogen sulfide and polysulfide in the central nervous system (2013)
  • Author(s): Kimura, H
  • Journal Title: Neurochem. Int Volume: 63 Pages: 492-497
  • DOI: 10.1016/j.neuint.2013.09.003
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide-mediated cellular signaling and cytoprotection (2013)
  • Author(s): Kimura, H
  • Journal Title: Hydrogen Sulfide and its Therapeutic Applications, Springer Wien Heidelberg New York Dordrecht London Pages: 181-202
  • Peer Reviewed
• [Journal Article] Polysulfide exerts a protective effect against cytotosxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells (2013)
  • Author(s): Koike, S., Ogasawara, Y., Shibuya, N., Kimura, H., Ishii, K
  • Journal Title: FEBS Lett Volume: 587 Pages: 3548-3555
  • DOI: 10.1016/j.febslet.2013.09.013
  • Peer Reviewed
• [Journal Article] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell (2012)
  • Author(s): Taniguchi, S., Kimura, T., Umeki, T., Kimura, Y., Kimura, H., Ishii, I., Itoh, N., Naito, Y., Ymamoto, H., Niki, I.
  • Journal Title: Molecular and Cellular Endochrinology Volume: 350 Pages: 31-38
  • DOI: 10.1016/j.mce.2011.11.016
  • Peer Reviewed
• [Journal Article] Metabolic turnover of hydrogen sulfide (2012)
  • Author(s): Kimura, H
  • Journal Title: Frontiers in Physiology Volume: 3(article 101) Pages: 1-3
  • DOI: 10.3389/fphys.2012.00101
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide is a signaling molecule and a cytoprotectant (2012)
  • Author(s): Kimura, H., Shibuya, N., Kimura, Y
  • Journal Title: Antioxid. Red. Signal Volume: 17 Pages: 45-57
  • DOI: 10.1089/ars.2011.4345
  • Peer Reviewed
• [Journal Article] Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice (2012)
  • Author(s): Tokuda, K., Kida, K., Marutani, E., Crimi, E., Bougaki, M., Khatri, A., Kimura, H., and Ichinose, F
  • Journal Title: Antioxid. Redox Signal Volume: 17 Pages: 11-21
  • DOI: 10.1089/ars.2011.4363
  • Peer Reviewed
• [Journal Article] A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide (2012)
  • Author(s): Mikami, Y., and Kimura, H
  • Journal Title: Commun Integr. Biol Volume: 5 Pages: 169-171
  • DOI: 10.4161/cib.18679
  • Peer Reviewed
• [Journal Article] The neurophysiology of hydrogen sulfide (2011)
  • Author(s): Rong, W., Kimura, H., and Grundy, D
  • Journal Title: Inflamm Allergy Drug Targets Volume: 10 Pages: 109-117
  • DOI: 10.2174/187152811794776295
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide : its production, release and functions (2011)
  • Author(s): Kimura, H
  • Journal Title: Amino Acids. Volume: 41 Pages: 113-121
  • DOI: 10.1007/s00726-010-0510-x
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide : Its production and functions (2011)
  • Author(s): Kimura, H
  • Journal Title: Exp. Physiol Volume: 96 Pages: 833-835
  • DOI: 10.1113/expphysiol
  • Peer Reviewed
• [Journal Article] Thioredoxin and dihydrolipoic acid are endogenous reductants required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide (2011)
  • Author(s): Mikami, Y. Shibuya, N., Kimura, Y., Ogasawara, Y., and Kimura, H
  • Journal Title: Biochem. J Volume: 439 Pages: 479-485
  • DOI: 10.1042/BJ20110841
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca^<2+> influx (2011)
  • Author(s): Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M., and Kimura, H
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 39379-39386
  • DOI: 10.1042/BJ20110841
  • Peer Reviewed
• [Journal Article] Development of a highly selective fluorescence probe for hydrogen sulfide (2011)
  • Author(s): Sasakura, K., Hanaoka, K., Shibuya, N., Mikami, Y., Kimura, Y., Komatsu, T., Ueno, T., Terai, T., Kimura, H., and Nagano, T
  • Journal Title: J. Am. Chem. Soc Volume: 133 Pages: 18003-18005
  • DOI: 10.1021/ja207851s
  • Peer Reviewed
• [Journal Article] The physiological role of hydrogen sulfide and beyond
  • Author(s): Kimura, H
  • Journal Title: Nitric Oxide Volume: (in press)
  • DOI: 10.1016/j.niox.2014.01.002
  • Peer Reviewed
• [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells (2014)
  • Author(s): Shibuya, N., Koike, S., Ishigami-Yuasa, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2014-03-04
• [Presentation] Polysulfides are potential H2S-derived signaling molecules that activate TRPA1 channels in rat brain (2014)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター, 仙台
  • Year and Date: 2014-03-03
• [Presentation] Hydrogen sulfide protects retina from light-induced degeneration (2014)
  • Author(s): Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2014-03-03
• [Presentation] H_2S production from D-cysteine and polysulfides as H_2S-derived signaling molecules (2013)
  • Author(s): Kimura, H
  • Organizer: The 13th International Congress on Amino Acids, Peptides and Proteins
  • Place of Presentation: Galveston Island Convention Center, Galvestone, USA
  • Year and Date: 20131005-07
  • Invited
• [Presentation] Open Plenary : Physiological function of hydrogen sulfide and beyond (2013)
  • Author(s): Kimura, H
  • Organizer: The 2nd European Conference on the Biology of Hydrogen Sulfide
  • Place of Presentation: Exeter University Convention Center, Exeter, UK
  • Year and Date: 20130908-11
  • Invited
• [Presentation] 生理活性物質H2S の新規生産経路 (2013)
  • Author(s): 渋谷 典広, 小池 伸, 湯浅(石上) 磨里, 田中 真紀子, 木村 由佳, 小笠原 裕樹, 福井 清, 永原 則之, 木村 英雄
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド, 神戸
  • Year and Date: 2013-12-05
• [Presentation] 硫化水素(H_2S)の生合成と機能 (2013)
  • Author(s): 木村英雄
  • Organizer: 第24回フォーラム イン ドージン生体硫化水素(bioH_2S)-原始環境が用意したシグナル分子-
  • Place of Presentation: 熊本ホテルキャッスル, 熊本
  • Year and Date: 2013-11-15
  • Invited
• [Presentation] Polysulfides are possible H_2S-derived signaling molecules in rat brain (2013)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2013-09-11
• [Presentation] 生理活性物質としての硫化水素(H_2S) (2013)
  • Author(s): 木村英雄
  • Organizer: 第9回Heme Oxytenase 研究フォーラム
  • Place of Presentation: 京都府立医科大学・青蓮会館, 京都
  • Year and Date: 2013-08-30
• [Presentation] Regulation of H2S production by cystathionine gamma-lyase by calcium (2013)
  • Author(s): Kimura, H, Mikami, Y., Shibuya, N., Ogasawara, Y
  • Organizer: Neuro2013
  • Place of Presentation: Kyoto International Conference Center, Kyoto.
  • Year and Date: 2013-06-20
• [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells (2013)
  • Author(s): Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nahahara, N., Kimura, H
  • Organizer: Neuro2013
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-20
• [Presentation] Signaling mechanism of hydrogen sulfide in astrocytes (2013)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
  • Organizer: Neuro2013
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-20
• [Presentation] 硫化水素選択的蛍光プローブの開発とその応用 (2013)
  • Author(s): 篠倉 潔, 花岡健二郎, 渋谷典広, 木村英雄, 長野哲雄
  • Organizer: 日本薬学会 第133年会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2013-03-28
• [Presentation] 硫化水素は, 神経細胞における硫化水素の細胞保護作用;グルタチオンの産生の増大と, ミトコンドリアにおける酸化的ストレスの抑制 (2013)
  • Author(s): 木村由佳, 後藤雄一, 木村英雄
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-22
• [Presentation] 硫化水素(H_2S)の生合成と光障害からの視神経保護 (2013)
  • Author(s): 木村英雄, 三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-22
• [Presentation] Another pathway to produce H2S in the brain (2012)
  • Author(s): Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場, 福岡
  • Year and Date: 2012-12-16
• [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress (2012)
  • Author(s): Kimura, Y., Goto, Y., Kimura, H
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] Regulation of H_2S production by 3-mercaptopyruvate sulfurtransferase (2012)
  • Author(s): Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Ogasawara, Y., Nagahara, N
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] 結合型イオウの神経細胞における生理機能の解析 (2012)
  • Author(s): 小池 伸, 小笠原裕樹, 渋谷典広, 木村英雄, 石井一行
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] CaMKIIおよびPKC による硫化水素生産酵素CBS のリン酸化について (2012)
  • Author(s): 土屋幸弘, 久野竜弥, 山田 薫, 波多野直哉, 渋谷典広, 木村英雄, 渡邊泰男
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] マウスにおける生理活性物質H2S の生産経路 (2012)
  • Author(s): 渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 福井清, 木村英雄
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場, 福岡
  • Year and Date: 2012-12-15
• [Presentation] Another pathway to produce H2S in the brain (2012)
  • Author(s): Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場, 名古屋
  • Year and Date: 2012-09-21
• [Presentation] H2S is a Signaling Molecule and a Cytoprotectant (2012)
  • Author(s): Kimura, H
  • Organizer: The Second International Conference on H2S Biology and Medicine
  • Place of Presentation: Sheraton Atlanta Hotel, Atlanta, USA
  • Year and Date: 2012-09-20
  • Invited
• [Presentation] Hydrogen sulfide (H2S) protects retinal photoreceptor cells from light-induced degeneration (2012)
  • Author(s): Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M., Kimura, H.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress (2012)
  • Author(s): Kimura, Y., Goto, Y., Kimura, H
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-19
• [Presentation] H_2S production by 3MST and its physi8ological role in the retina (2012)
  • Author(s): Kimura, H
  • Organizer: The First European Conference on the Biology of H_2S
  • Place of Presentation: Smolenice Castle, Blatislava, Slovakia
  • Year and Date: 2012-06-17
  • Invited
• [Presentation] H2S signaling : from hypothesis to function in the nervous system (2012)
  • Author(s): Kimura, H
  • Organizer: Experimental Biology 2012
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2012-04-24
  • Invited
• [Presentation] マウス脳における新規のH2S生産経路 (2011)
  • Author(s): 渋谷典広, 田中真紀子, 石上磨里, 木村由佳, 小笠原裕樹, 木村英雄
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会議場, 京都
  • Year and Date: 2011-09-24
• [Presentation] 3-メルカプトピルビン酸イオウ転位酵素の硫化水素生産補因子 (2011)
  • Author(s): 木村英雄, 三上義礼, 渋谷典広, 木村由佳, 永原則之, 小笠原裕樹
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 網膜における硫化水素の生合成と細胞保護作用 (2011)
  • Author(s): 三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘, 木村英雄
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] Neuroprotection by hydrogen sulfide; Suppression of oxidative stress in mitochondria by increasing glutathione levels (2011)
  • Author(s): Yuka Kimura, Yu-ichi Goto, Hideo Kimura
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] 硫化水素は酸化的ストレスから神経細胞を保護する (2011)
  • Author(s): 木村由佳, 後藤雄一, 木村英雄
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2011-09-17
• [Presentation] H2S生産酵素3MSTの補因子の探索 (2011)
  • Author(s): 木村英雄, 三上義礼, 渋谷典広, 木村由佳, 小笠原裕樹
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 脳における硫化水素生産酵素の探索 (2011)
  • Author(s): 渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 木村英雄
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 網膜におけるH 2Sの生産制御とその細胞保護作用の解析 (2011)
  • Author(s): 三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘, 木村英雄
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Hydrogen sulfide is a cytoprotectant from oxidative stress (2011)
  • Author(s): Kimura H
  • Organizer: The 2nd Polish Congress of Biochemistry and Cell Biology (The 46th Meeting of the Polish Biochemical Society, The 11th Conference of the Polish Cell Biology Society)
  • Place of Presentation: Jagiellonian University Convention Center, Krakow
  • Year and Date: 2011-09-08
  • Invited
• [Presentation] The production and function of hydrogen sulfide. In Gasotransmitter and signal transduction (2011)
  • Author(s): Kimura H
  • Organizer: The 2nd Polish Congress of Biochemistry and Cell Biology (The 46th Meeting of the Polish Biochemical Society, The 11th Conference of the Polish Cell Biology Society)
  • Place of Presentation: Jagiellonian University Convention Center, Krakow
  • Year and Date: 2011-09-06
  • Invited
• [Presentation] H2S production and its neuroprotective effect. In Sulfur amino acid (2011)
  • Author(s): Kimura H
  • Organizer: 12th International Congress on amino acids, peptides and proteins
  • Place of Presentation: Beijing International Convention Center, Beijing
  • Year and Date: 2011-08-01
  • Invited
• [Presentation] 企画講演IV 毒ガス硫化水素の医療応用 (2011)
  • Author(s): 木村英雄
  • Organizer: 第26回日本老年精神医学会
  • Place of Presentation: 京王プラザホテル, 東京
  • Year and Date: 2011-06-17
  • Invited
• [Presentation] Hydrogen sulfide : its production and functions. In Emerging roles for gasotransmitters (2011)
  • Author(s): Kimura H
  • Organizer: Experimental Biology 2011
  • Place of Presentation: Washington Convention Center, Washington DC
  • Year and Date: 2011-04-12
  • Invited
• [Presentation] 硫化水素の機能と医療応用 (2011)
  • Author(s): 木村英雄
  • Organizer: 分子状水素医学シンポジウム
  • Place of Presentation: 名古屋大学医学部附属病院3階講堂, 名古屋
  • Year and Date: 2011-02-19
  • Invited
• [Presentation] 硫化水素 : 生合成, 放出, 生理機能
  • Author(s): 木村英雄
  • Organizer: 第84回日本薬理学会, シンポジウム
  • Place of Presentation: 誌上開催
• [Presentation] 脳における硫化水素の生産酵素
  • Author(s): 渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 木村英雄
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: 震災で中止
• [Presentation] 硫化水素はグルタチオンの産生の増大と, ミトコンドリアにおける酸化ストレスの抑制により, 神経細胞を酸化的ストレスから保護する
  • Author(s): 木村由佳, 後藤雄一, 木村英雄
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: 震災で中止
• [Presentation] H2Sの生産制御と細胞保護作用
  • Author(s): 三上義礼, 渋谷典広, 木村由佳, 小笠原裕樹, 永原則之, 木村英雄
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: 震災で中止
• [Book] Hydrogen sulfide-mediated cellular signaling and cytoprotection. In Hydrogen Sulfide and its Therapeutic Applications. (2013)
  • Author(s): Kimura, H(Ed by Hideo Kimura)
  • Total Pages: 181-202
  • Publisher: Springer Wien Heidelberg New York Dordrecht London
• [Book] Physiological and pathophysiological functions of hydrogen sulfide. In Gasotransmitters: Physiology and Pathophysiology. (2012)
  • Author(s): Kimura, H(Ed. By Anton Herman, Guezel F. Sitdikova, and Thomas M. Weiger)
  • Total Pages: 71-98
  • Publisher: Springer Heidelberg New York Dordrecht London
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r_dna/index.html
• [Patent(Industrial Property Rights)] D-システインを有効成分として含有する硫化水素産生誘導剤 (2013)
  • Inventor(s): 木村英雄, 渋谷典広
  • Industrial Property Rights Holder: 発明者, 国立精神・神経医療研究センター, 大塚製薬工場
  • Industrial Property Rights Type: 国際出願
  • Industrial Property Number: PCT/JP2013/004428
  • Filing Date: 2013-07-19
  • Overseas