2012 Fiscal Year Final Research Report
The promotion of hepatic regeneration by lipid droplet's proteins operation
| Project/Area Number |
23659094
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Toyoshi 名古屋大学, 大学院・医学系研究科, 教授 (50115929)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI Hisaaki 徳島大学, 疾患酵素学研究センター, 教授 (10257636)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脂肪滴 / 部分肝切除 |
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| Research Abstract |
Lipid droplet metabolism is essential for liver regeneration. The aim of this study is to promote liver regenerationby controlling a degradation of protein on LD. In this study, we found that UBXD8 and p97/VCP are localized on LDs, and that they are engaged in apolipoprotein B degradation around LDs. Furthermore, we showed that UBXD8 participated in degradation of LD-associated proteins as well as lipid metabolism in LDs. Further studies on UBXD8 should help develop a new technique that promotes liver regeneration.
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