Therapeutic strategies for diabetic complications by using Imatinib

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659098
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
• Project Period (FY): 2011 – 2012
• Keywords: 糖尿病合併症 / 肝臓 / 腎臓 / イマチ二ブ / 骨髄由来細胞

Research Abstract

Results showed that imatinib inhibits the infiltration of abnormalbone marrow-derived cells into peripheral organs and blocked TNFα expression in thekidney and liver of diabetic animals. Therefore imatinib has a therapeutic potential fordiabetic complications.

Research Products

• [Journal Article] Bone marrow stem cell abnormality and diabetic complications (2012)
  • Author(s): Fujimiya M, Nagaishi K, Yamashita T,Ataka K
  • Journal Title: Anat Rec (Hoboken) Volume: 295 Pages: 917-21
  • DOI: DOI:10.1002/ar.22445
  • Peer Reviewed
• [Journal Article] Fusion of bonemarrow-derived cells with renal tubulescontributes to renaldysfunction in diabeticnephropathy (2012)
  • Author(s): Yamashita T, Fujimiya M, Nagaishi K,Ataka K, Tanaka M, Yoshida H, Tsuchihashi K,Shimamoto K, Miura T
  • Journal Title: FASEB J Volume: 26 Pages: 1559-68
  • DOI: DOI:10.1096/fj.11-183194
  • Peer Reviewed
• [Journal Article] 糖尿病合併症における骨髄細胞の意義 (2012)
  • Author(s): 藤宮峯子
  • Journal Title: 循環器内科 Volume: 72巻 Pages: 426-430
  • Peer Reviewed
• [Presentation] 骨髄間葉系幹細胞を用いた糖尿病性肝障害に対する新規治療法 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本再生医療会
  • Place of Presentation: 横浜
  • Year and Date: 20130000
• [Presentation] 骨髄間葉系幹細胞を用いた糖尿病合併症の治療 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本解剖学会
  • Place of Presentation: 高松
  • Year and Date: 20130000
• [Presentation] 糖尿病における骨髄幹細胞の異常 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本解剖学会
  • Place of Presentation: 高松
  • Year and Date: 20130000