2012 Fiscal Year Final Research Report
Common and distinct mechanisms for ARF6-mediated neuronal migration and cancer invasion
| Project/Area Number |
23659101
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 神経細胞 / がん細胞 / アクチン骨格 / 小胞輸送 / 運動性 / 低分子量 GTP 結合タンパク質 |
|---|
| Research Abstract |
ADP ribosylation factor is a small GTPase that regulate membrane traffic and actin remodeling through the activation of lipid modifying enzymes and recruitment of various interacting proteins such as FIP3/4 and JIP3/4. Recent evidence indicates the functional importance of ARF6 pathways in cell motility such as cancer invasion and metastasis. The aim of this study is to test the possibility whether the ARF6 pathway may be involved in neuronal migration during cortical layer formation. We found that type I phosphatidylinositol 4-phosphate 5-kinase r (PIP5KIr), a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-synthesizing enzyme that functions as a downstream effector of Arf6, is required for neuronal migration possibly through recruitment of adhesion components to the plasma membrane.
|
Research Products
(32 results)
-
-
-
-
-
-
-
[Journal Article] Accumulation of a-synuclein triggered by presynaptic dysfunction2012
Author(s)
Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, Hayakawa H, Kawanami A, Kataoka M, Nagai M, Sakagami H, Takahashi M, Mizuno Y, Mochizuki H
-
Journal Title
J. Neurosci
Volume: 32
Pages: 17186-17196
Peer Reviewed
-
[Journal Article] Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment2012
Author(s)
Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M
-
Journal Title
Toxicol Appl Pharmacol
Volume: 259
Pages: 104-114
Peer Reviewed
-
-
[Journal Article] SynArfGEF is a guanine nucleotide exchage factor for Arf6 and localizes preferentially at post-synaptic specialization of inhibitory synapases2011
Author(s)
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H
-
Journal Title
J. Neurochem
Volume: 116
Pages: 1122-1137
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis - appropriate for general orthopaedic surgeons?2011
Author(s)
Takaso M, Nakazawa T, Imura T, Fukushima K, Ueno M, Saito W, Shintani R, Sakagami H, Takahashi K, Yamazaki M, Ohtori S, Kotani T
-
Journal Title
International Orthopaedics
Volume: 35
Pages: 67-73
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
