• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Common and distinct mechanisms for ARF6-mediated neuronal migration and cancer invasion

Research Project

  • PDF
Project/Area Number 23659101
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKitasato University

Principal Investigator

SAKAGAMI Hiroyuki  北里大学, 医学部, 教授 (90261528)

Project Period (FY) 2011 – 2012
Keywords神経細胞 / がん細胞 / アクチン骨格 / 小胞輸送 / 運動性 / 低分子量 GTP 結合タンパク質
Research Abstract

ADP ribosylation factor is a small GTPase that regulate membrane traffic and actin remodeling through the activation of lipid modifying enzymes and recruitment of various interacting proteins such as FIP3/4 and JIP3/4. Recent evidence indicates the functional importance of ARF6 pathways in cell motility such as cancer invasion and metastasis. The aim of this study is to test the possibility whether the ARF6 pathway may be involved in neuronal migration during cortical layer formation. We found that type I phosphatidylinositol 4-phosphate 5-kinase r (PIP5KIr), a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-synthesizing enzyme that functions as a downstream effector of Arf6, is required for neuronal migration possibly through recruitment of adhesion components to the plasma membrane.

  • Research Products

    (32 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Type I phosphatidylinositol 4-phosphate 5-kinase r is required for neuronal migration in the mouse developing cerebral cortex2013

    • Author(s)
      Hara Y, Fukaya M, Tamaki H, Sakagami H
    • Journal Title

      Eur. J. Neurosci

    • Peer Reviewed
  • [Journal Article] EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis2013

    • Author(s)
      Ueda T, Hanai A, Takei T, Kubo K, Ohgi M, Sakagami H, Takahashi S, Shin HW, Nakayama K
    • Journal Title

      FEBS Lett

      Volume: S0014- 5793(13) Pages: 00298-6

    • Peer Reviewed
  • [Journal Article] Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina2013

    • Author(s)
      Sakagami H, Katsumata O, Hara Y, Tamaki H, Watanabe M, Harvey RJ, Fukaya M
    • Journal Title

      J. Comp. Neurol

      Volume: 521 Pages: 860-876

    • Peer Reviewed
  • [Journal Article] Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment2013

    • Author(s)
      Song N, Nakagawa S, Izumi T, Toda H, Kato A, Boku S, Inoue T, Sakagami H, Li X, Koyama T
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 16(4) Pages: 803-812

    • Peer Reviewed
  • [Journal Article] Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure2012

    • Author(s)
      Tamaki H, Sanda M, Katsumata O, Hara Y, Fukaya M, Sakagami H
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 3064-3070

    • Peer Reviewed
  • [Journal Article] Inducible and Conditional Deletion of Extracellular Signal-regulated Kinase 5 Disrupts Adult Hippocampal Neurogenesis2012

    • Author(s)
      Pan YW, Zou J, Wang W, Sakagami H, Garelick MG, Abel G, Kuo CT, Storm DR, Xia Z
    • Journal Title

      J Biol Chem

      Volume: 287(28) Pages: 23306-23317

    • Peer Reviewed
  • [Journal Article] Accumulation of a-synuclein triggered by presynaptic dysfunction2012

    • Author(s)
      Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, Hayakawa H, Kawanami A, Kataoka M, Nagai M, Sakagami H, Takahashi M, Mizuno Y, Mochizuki H
    • Journal Title

      J. Neurosci

      Volume: 32 Pages: 17186-17196

    • Peer Reviewed
  • [Journal Article] Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment2012

    • Author(s)
      Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 259 Pages: 104-114

    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer2012

    • Author(s)
      Katoh H, Yamashita K, Waraya M, Margalit O, Ooki A, Tamaki H, Sakagami H, Kokubo K, Sidransky D, Watanabe M
    • Journal Title

      Neoplasia

      Volume: 14 Pages: 559-571

    • Peer Reviewed
  • [Journal Article] SynArfGEF is a guanine nucleotide exchage factor for Arf6 and localizes preferentially at post-synaptic specialization of inhibitory synapases2011

    • Author(s)
      Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H
    • Journal Title

      J. Neurochem

      Volume: 116 Pages: 1122-1137

    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity2011

    • Author(s)
      Kato T, Ito Y, Hosono K, Suzuki T, Tamaki H, Minamino T, Kato S, Sakagami H, Shibuya M, Majima M
    • Journal Title

      Toxicol Sci

      Volume: 120 Pages: 218-229

    • Peer Reviewed
  • [Journal Article] Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation2011

    • Author(s)
      Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K,Majima M
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 1049-1058

    • Peer Reviewed
  • [Journal Article] Differential expression of SNAP-25 family proteins in the mouse brain2011

    • Author(s)
      Yamamori S, Itakura M, Sugaya D, Katsumata O, Sakagami H, Takahashi M
    • Journal Title

      J. Comp. Neurol

      Volume: 519 Pages: 916-932

    • Peer Reviewed
  • [Journal Article] Locomotor-related activity of GABAergic interneurons localized in the ventrolateral region in the isolated spinal cord of neonatal mice2011

    • Author(s)
      Nishimaru H, Sakagami H, Kakizaki M, Yanagawa Y
    • Journal Title

      J Neurophysiol

      Volume: 106 Pages: 1782- 1792

    • Peer Reviewed
  • [Journal Article] Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice2011

    • Author(s)
      Isono M, Suzuki T, Hosono K, Hayashi I, Sakagami H, Uematsu S, Akira S, DeClerck YA, Okamoto H, Majima M
    • Journal Title

      Life Sci

      Volume: 88 Pages: 693-700

    • Peer Reviewed
  • [Journal Article] Less invasive and less technically demanding decompressive procedure for lumbar spinal stenosis - appropriate for general orthopaedic surgeons?2011

    • Author(s)
      Takaso M, Nakazawa T, Imura T, Fukushima K, Ueno M, Saito W, Shintani R, Sakagami H, Takahashi K, Yamazaki M, Ohtori S, Kotani T
    • Journal Title

      International Orthopaedics

      Volume: 35 Pages: 67-73

    • Peer Reviewed
  • [Presentation] xpression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) r in the developing cerebral cortex2013

    • Author(s)
      原芳伸、深谷昌弘、玉木英明、阪上洋行
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      20130328-30
  • [Presentation] Splice variantdependent subcellular localization of the Arf6 activator BRAG2 in the adult mouse brain2013

    • Author(s)
      深谷昌弘、阪上洋行
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      20130328-30
  • [Presentation] Arf6 の 下 流 効 果 分 子 Rab11-FIP3/Arfophilin-1 の神経細胞の樹状突起における役割2013

    • Author(s)
      矢崎佑紀、原芳伸、深谷昌弘、阪上洋行
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      20130328-30
  • [Presentation] ARF6 活性制御因子 BRAG2/IQSEC1 のスプライスバリアント依存的なシナプス局在2012

    • Author(s)
      深谷昌弘、原芳伸、阪上洋行
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] 成熟マウス脳における EFA6A とおよびその結合分子 SNX1 の細胞内局在解析2012

    • Author(s)
      福島大輔、深谷昌弘、阪上洋行
    • Organizer
      第35回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) r in the developing cerebral cortex2012

    • Author(s)
      原芳伸、阪上洋行
    • Organizer
      第8回欧州神経科学会 (FENS)
    • Place of Presentation
      スペイン
    • Year and Date
      20120714-18
  • [Presentation] DISTINCT LOCALIZATION OF THE BRAG/IQSEC FAMILY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR ARF6 IN THE MOUSE RETINA2012

    • Author(s)
      阪上洋行、原芳伸、深谷昌弘
    • Organizer
      第8回欧州神経科学会 (FENS)
    • Place of Presentation
      スペイン
    • Year and Date
      20120714-18
  • [Presentation] 成熟マウス脳における Arf6 活性化制御因子EFA6A の細胞内局在解析2012

    • Author(s)
      福島大輔、深谷昌弘、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-28
  • [Presentation] 成体マウス脳におけるARF6活性化因子BRAG2/IQSEC1 の細胞内局在解析2012

    • Author(s)
      深谷昌弘、原芳伸、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-28
  • [Presentation] マウス小脳プルキンエ細胞の生後発生過程におけるゴルジ装置の動態2012

    • Author(s)
      玉木英明、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-27
  • [Presentation] 大脳皮質層形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2012

    • Author(s)
      原芳伸、阪上洋行
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-26
  • [Presentation] 大脳皮質形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2011

    • Author(s)
      原芳伸、西村伸彦、深谷昌弘、玉木英明、阪上洋行
    • Organizer
      第99回日本解剖学関東支部学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-15
  • [Presentation] 中枢神経系における ARF6 活性化制御因子 EFA6Aの細胞内局在解析2011

    • Author(s)
      福島大輔、深谷昌弘、阪上洋行
    • Organizer
      第99回日本解剖学関東支部学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-15
  • [Presentation] 成熟期マウス脳における BRAG2/GEP100 の細胞内局在解析2011

    • Author(s)
      深谷昌弘、原芳伸、阪上洋行
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
  • [Presentation] 大脳皮質層形成における PIP5Kgamma の発現機能解析2011

    • Author(s)
      原芳伸、西村伸彦、阪上洋行
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
  • [Remarks] 北里大学医学部解剖学教室ホームページ

    • URL

      http://www.med.kitasato-u.ac.jp/~sakagami/

URL: 

Published: 2014-09-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi