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2012 Fiscal Year Final Research Report

Biosynthesis of heparin proteoglycan (serglycin)

Research Project

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Project/Area Number 23659108
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YANAGISHITA Masaki  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70132793)

Co-Investigator(Kenkyū-buntansha) KATARZYNA ANNA Podyma-Inoue   (90302877)
Project Period (FY) 2011 – 2012
Keywords血液凝固 / レオロジー
Research Abstract

Heparin is a biological product having anticoagulant activity. It is widely used in heart-lung surgeries, hemodialysis, and in the treatment of arterial/venous thromboses. Biosynthetic processes involved in the processing of heparin, especially that of carbohydrate chains after completion in Golgi until the storage of the final products in secretion granules, have not been elucidated. The current research attempted to analyze this processes in detail, and has reached a conclusion that the “heparanase” is the key enzyme in this process and the newly generated non-reducing ends of heparin chains weresuggested to have specific functions.

  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (6 results) Presentation (13 results)

  • [Journal Article] Degradation of MUC7 and MUC5B in Human Saliva2013

    • Author(s)
      Sachiko Takehara, Masaki Yanagishita, Katarzyna Anna Podyma-Inoue and Yoko Kawaguchi
    • Journal Title

      PLOS ONE

      Volume: (in press)

  • [Journal Article]2013

    • Author(s)
      Miki Hara-Yokoyama, Kazue Terasawa, Shizuko Ichinose, Akihiko Watanabe, Katarzyna A. Podyma-Inoue, Kazunari Akiyoshi, Yasuyuki Igarashi and Masaki Yanagishita
    • Journal Title

      Bioorganic & Madicinal Chemistry letter

      Volume: (in press)

  • [Journal Article]2012

    • Author(s)
      Miki Hara-Yokoyama, Mutsuko Kukimoto-Niino, Kazue Terasawa, Satoru Harumiya, Katarzyna A. Podyma-Inoue, Nobumasa Hino, Kensaku Sakamoto, Satsuki Itoh, Noritaka Hashii, Yoko Hiruta, Nana Kawasaki, Chiemi Mishima- Tsumagari, Yoko Kaitsu, Tomoko Matsumoto, Motoaki Wakiyama, Mikako Shirouzu, Takeshi Kasama, Hiroshi Takayanagi, Nakako Utsunomiya-Tate, Kiyoshi Takatsu, Toshiaki Katada, Yoshio Hirabayashi, Shigeyuki Yokoyama and Masaki Yanagishita
    • Journal Title

      Structure

      Volume: 20 Pages: 1585-1595

  • [Journal Article] The proteoglycan repertoire of lymphoid cells2012

    • Author(s)
      Bodil Fadnes, Anne Husbekk, Gunbjorg Sveing, Oystein Rekdal, Masaki Yanagishita, Svein O. Kolset and Lars Uhlin-Hansen
    • Journal Title

      Glycoconjugate

      Volume: J.29 Pages: 513-523

  • [Journal Article] Syndecans Reside in Sphingomyelin-enriched Low Density Fractions of the Plasma membrane Isolated from a Parathyroid Cell Line2012

    • Author(s)
      Katarzyna A. Podyma-Inoue, Miki Yokoyama, Tomoko Kimura and Masaki Yanagishita
    • Journal Title

      PLOS ONE

      Volume: 7:3 Pages: e32351

  • [Journal Article] Periodontal pockets as the pathological setting for HMGB1 release2011

    • Author(s)
      N. Ebe, M. Hara-Yokoyama, K. Iwasaki, S. Iseki, K. Terasawa, K. A. Podyma-Inoue, M.Yanagishita and Y. Izumi
    • Journal Title

      J. Dental Res

      Volume: 90 Pages: 235-240

  • [Presentation] Introduction, turnover and degradation of hyaluronan2013

    • Author(s)
      Masaki Yanagishita
    • Organizer
      2013 International Society for Hyaluronan Sciences Meeting
    • Place of Presentation
      Oklahoma City, OK, USA
    • Year and Date
      20130602-07
  • [Presentation] Expression of GIP and itsreceptor in the rat major salivary glands2012

    • Author(s)
      Privatananupunt Jutiporn, WatariIppei, Podyma-Inoue Katarzyna A.,Kubono Mariko, Hattori Ikuko, Honda Koji, Ishida Yuji, Yanagishita Masaki, and Ono Takashi
    • Organizer
      71st Annual Meeting of the JapaneseOrthodontic Society
    • Place of Presentation
      Morioka
    • Year and Date
      20120926-28
  • [Presentation] Association of heparan sulphate proteoglycan sith trypsin-accessible membrane domains2012

    • Author(s)
      Katarzyna A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita
    • Organizer
      Gordon Research Conference on Poteoglycan
    • Place of Presentation
      Andover, NH, USA
    • Year and Date
      20120707-13
  • [Presentation] Proteolytic Degradation of Human Salivary MUC5B and MUC72012

    • Author(s)
      S. Takehara, M. Yanagishita, K. A. Podyma-Inoue, M. Ueno, K. Shinada and Y. Kawaguchi
    • Organizer
      Annual Meeting of International Association for Dental Research
    • Place of Presentation
      San Diego
    • Year and Date
      20120316-19
  • [Presentation] プロテオグライカン、ヒアルロン酸研究の最新トピックス2012

    • Author(s)
      柳下正樹
    • Organizer
      第19回プロテオグライカンフォーラム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2012-02-11
  • [Presentation] CD38の触媒活性と膜ドメイン局在化を両立させている細胞表面でのアセンブリの構造基盤2011

    • Author(s)
      Yokoyama Miki, Yokoyama Shigeyuki, Yanagishita Masaki
    • Organizer
      2011日本免疫学会総会
    • Place of Presentation
      日幕張メッセ
    • Year and Date
      20111127-29
  • [Presentation] 酪酸による酸化ストレス誘導時に放出されるHMGB1の解析2011

    • Author(s)
      江部典子、横山三紀、寺澤和恵、柳下正樹、和泉雄一
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      大阪
    • Year and Date
      20111020-21
  • [Presentation] Characterization of Membrane Rafts Enriched in Cell Surface Haparan Sulfate Proteoglycans Isolated from a RatParathyroid Cell Line2011

    • Author(s)
      Katarzyne A. Podyma-Inoue, Miki Yokoyama and Masaki Yanagishita
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      20110921-24
  • [Presentation] GM2/GD2合成酵素欠損マウスにおける血液-精巣関門の異常2011

    • Author(s)
      横山三紀、市野瀬志津子、市野瀬省三、多田晃弘、寺澤和恵、吉垣純子、只野-有冨桂子、古川鋼一、柳下正樹、岩渕和久
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      20110921-24
  • [Presentation] Analysis of neurotransmitters/neuromodulators released under low gravity usingmicrodialysis technique2011

    • Author(s)
      Katarzyna A. Inoue, Kimiya Norikiyo, Jorge L. Zaredo, Akira Masuda, Shuji Aou and Yasuhiro Kumei
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      20110914-17
  • [Presentation] リンパ球表面抗原CD38の4量体化を反映したN型糖鎖プロセシング2011

    • Author(s)
      横山三紀、新野睦子、寺澤和恵、橋井則貴、蛭田葉子、川崎ナナ、脇山素明、白水美香子、横山茂之、柳下正樹
    • Organizer
      第30回日本糖質学会
    • Place of Presentation
      長岡
    • Year and Date
      20110711-13
  • [Presentation] Proteolytic Degradation of Human Salivary MUC5B and MUC7, Symposium2011

    • Author(s)
      S. Takehara, M. Yanagishita, K. A. Podyma-Inoue, M. Ueno, K. Shinada and Y. Kawaguchi
    • Organizer
      Toward networking dental professionals in Asia
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-10-06
  • [Presentation] Life is not only wine and roses"? - climbing up Japanese social ladder2011

    • Author(s)
      Katarzyna Inoue
    • Organizer
      第84回日本生化学会ランチョンワークショップ
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22

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Published: 2014-09-25  

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