2014 Fiscal Year Final Research Report
Elucidation of mechanism for production of causal factor of vasospasm
| Project/Area Number |
23659113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KOBAYASHI Sei 山口大学, 医学(系)研究科(研究院), 教授 (80225515)
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| Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroko 山口大学, 大学院医学系研究科, 准教授 (40359899)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 病態生理 / 血管攣縮 / 血管異常収縮 / 血管病 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the molecular mechanism of causal factor of vasospasm, SPC. Surprisingly, SPC was not produced by the enzymatic reaction, but by the non-enzymatic reaction. We discovered that OH radical plays an essential role of the non-enzymatic production of SPC.
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| Free Research Field |
分子細胞生理学
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