2012 Fiscal Year Final Research Report
Elucidation of hypotonicity-induced suppression mechanism of vasopressin secretion through identification of hypoosmolarity sensor
| Project/Area Number |
23659118
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Kaori (NUMATA Kaori) 生理学研究所, 細胞器官研究系, NIPS リサーチフェロー (60614196)
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| Co-Investigator(Renkei-kenkyūsha) |
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 浸透圧センサー / バソプレシン視索上核 / アニオンチャネル / タウリン / グリシンレセプター |
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| Research Abstract |
Arginine-vasopressin (AVP), an antidiuretic hormone, is secreted from AVP neurons in a manner sensitive to body fluid osmolarity. The current view for the hypotonicity-induced suppression mechanism consists of following two hypotheses: Reduced depolarization due to inactivation of stretch-inactivated cation channel (SIC) in osmotically swollen AVP neurons, and increased hyperpolarization due to glycine receptor (GlyR) activation in AVP neurons in response to taurine released from osmotically swollen glial cells. In rat AVP neurons, in the present study, the SIC activity was not observed, and taurine-induced activation of GlyR brought about depolarization but not hyperpolarization under hypotonic conditions. Also, the present study showed that taurine-releasing anion channel activated by cell swelling serves as a sensor for hypoosmolarity.
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Research Products
(11 results)
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[Remarks] 生理学研究所HP&機能協関研究部門 HP:公開日 2013.01.31 抗酸化物質グルタチオンが細胞から放出 される「通り道」を発見:Sabirov RZ, Kurbannazarova RS, Melanova NR, Okada Y. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. PLoS One, 2013
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[Remarks] 生理学研究所HP&機能協関研究部門 HP:公開日 2012.01.24 細胞容積調節におけるABCF2 とα-アク チニン-4 の分子間相互作用の役割: Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y. Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells. J Cell Physiol, 2012.
