Effect of Corticotropin-Releasing Hormone ( CRH ) and CRH Receptor1 ( CRH-R1 ) Gene Variants in Human Endometrial Cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 23659120
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tohoku University
• Principal Investigator: SATO Naoko 東北大学, 医学(系)研究科(研究院), 助教 (40457750)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takashi 東北大学, 大学院医学系研究科, 教授 (10261629)
• Research Collaborator: FUKUDO Shin 東北大学, 大学院医学系研究科, 教授 (80199249)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: がん / ストレス / CRH / QOL

Outline of Final Research Achievements

Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1
(CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in　several types of carcinoma.In our study results, CRH, CRHR1, and CRHR2 immunoreactivitywas detected in the cytoplasm of endometrial carcinoma cells. And suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease.

Free Research Field

がん　ストレス　CRH　健康関連QOL