2013 Fiscal Year Final Research Report
The search of factors to induce mitochondrial biogenesis, and the analysis of its cellular functions
| Project/Area Number |
23659122
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJITA Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20423288)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | ミトコンドリア / 機能性化合物 / エネルギー代謝 / 酸化ストレス / 筋管細胞 |
|---|
| Research Abstract |
The decrease of the mitochondrial quantity and function is associated with the onset of the various disease including life-style related diseases. Therefore, that the compound to make increase mitochondrial quantity contributes to treatment and prevention of the mitochondrial associated diseases is expected. In this study, we found that several kinds of compounds increased mitochondrial quantity in murine skeletal muscle cells. Also, cells treated with a compound got resistance against the oxidative stress, and the compounds were found to increase the cellular functions. These compounds are promising to practical use in the therapies aimed at enhancement of mitochondrial quantity and functions.
|
-
-
-
[Journal Article]2012
Author(s)
Kobuchi H, Moriya K, Ogino T, Fujita H, Inoue K, Shuin T, Yasuda T, Utsumi K, and Utsumi T
-
Journal Title
PLoS ONE
Volume: vol.7(11)
Pages: e50082
DOI
Peer Reviewed
-
[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells2011
Author(s)
Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, and Utsumi K
-
Journal Title
Molecular and CellularBiochemistry
Volume: vol.358
Pages: 297-307
DOI
Peer Reviewed
-
-
-
-
-
-
-
