2012 Fiscal Year Final Research Report
Effect of drugs of abuse on reward-based decision-making in rodents
| Project/Area Number |
23659135
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIZOGUCHI Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 覚せい剤 / 薬物依存症 / ギャンブルテスト / 意思決定 |
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| Research Abstract |
In the present study, we developed a gambling testfor rodents using a radial-arm maze to address the issue of decision-making in patients with drug dependence. Rats were trained in the cost/benefit decision-making task, in which they chose one of four arms [one low risk/low return (LL) arm, one high risk/high return (HH) arm and two empty arms]. The test consisted of consecutive 16 trials a day. Following extensive testing, naive rats showed the choice behavior, which is dependent on reward probability and reward value of the arms. Following chronic treatment with methamphetamine, the animals chose HH arms more frequently than did saline-treated control rats. After the gambling test, c-Fos expression was markedly increased in the insular cortex, striatum, and nucleus accumbens of methamphetamine-dependent rats compared to saline-treated control rats. Our findings suggest that chronic methamphetamine treatment may lead to alternations of reward-based decision-making. Aberrant activation of the cortico-striatal pathway from insular cortex to striatum may be associated with the impairment of reward-based decision-making in methamphetamine-dependent rats.
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Research Products
(9 results)
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[Journal Article] Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.2011
Author(s)
Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J and Yamada K
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Journal Title
J Neurosci
Volume: 31
Pages: 12963-12971
DOI
Peer Reviewed
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[Presentation]2012
Author(s)
溝口博之、山田清文
Organizer
第35回日本神経科学大会
Place of Presentation
名古屋 名古屋国際会議場
Year and Date
20120918-21
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