2012 Fiscal Year Final Research Report
Identification of novel drug targets with Omics-based mechanismsfor obesity treatment
| Project/Area Number |
23659136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Mie University |
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Principal Investigator |
TANAKA Toshio 三重大学, 大学院・医学系研究科, 教授 (00135443)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Yuuhei 三重大学, 大学院・医学系研究科, 講師 (30303720)
SHIMADA Yasuhito 三重大学, 大学院・医学系研究科, 助教 (40378427)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 創薬・ゲノム薬理学 |
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| Research Abstract |
We found new candidate genes for obesity treatment using DNA microarray experiments and pathway analyses with zebrafish model of diet-induced obesity. Gene knockdown studies of these candidates using morpholino antisense oligonucleotides revealed that several genes including mxd3 could ameliorated the disease phenotypes in model animals. In addition, we clarify the mechanism of these therapeutic effects by Omics research approach.
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Research Products
(11 results)
