2012 Fiscal Year Final Research Report
Roles of p40phox in Crohn disease and its application for drug development
Project/Area Number |
23659137
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Kobe University |
Principal Investigator |
SAITOU Naoaki 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 教授 (60178499)
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Co-Investigator(Kenkyū-buntansha) |
UEYAMA Takehiko 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 准教授 (80346254)
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Co-Investigator(Renkei-kenkyūsha) |
KUSUNOKI Masato 三重大学, 医学(系)研究科(研究院) (50192026)
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Project Period (FY) |
2011 – 2012
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Keywords | クローン病 / p40phox / 活性酸素 / NADPH / oxidase |
Research Abstract |
On the basis of our hypothesis that the etiology of Crohn’s disease is related with that of CGD enteritis due to p40phox gene abnormality, we examined the new cause of Crohn disease and its treatment. We examined the production of reactive oxygen, and p40phox gene mutations in treatment-resistant of the six cases the (refractory) patients with Crohn's disease, but we were not able to discover the CGD enteritis patients due to p40phox gene abnormality.
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Research Products
(30 results)
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[Journal Article] Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release2012
Author(s)
Sakuma, M., Shirai, Y., Yoshino, K-I., Kuramasu, M., Nakamura, T., Yanagita, T., Mizuno, K., Hide, I., Nakata, Y., Saito, N.
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Journal Title
Mol Biol Cell
Volume: 23(18)
Pages: 3707-3721
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[Journal Article] Establishment of a Novel Fluorescence-Based Method to Evaluate Chaperone-Mediated Autophagy in a Single Neuron.2012
Author(s)
Seki, T., Ken-ich Yoshino, K., Tanaka, S., Dohi, E., Onji, T., Yamamoto, K., Hide, I., Paulson, H.L., Saito, N., Sakai, N
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Journal Title
PLoS ONE
Volume: 7(2)
Pages: e31232
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[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase αby phosphorylation at Tyr2182012
Author(s)
Matsubara, T., Ikeda, M., Kiso, Y., Sakuma, M., Yoshino, K-I., Sakane, F., Merida, I., Saito, N. and Shirai, Y
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 5507-5517
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[Journal Article] Cooperation of p40phox with p47phox for Nox2 activation during FcγR-mediated phagocytosis --Mechanism for acquisition of p40phox PI(3)P binding--2011
Author(s)
Ueyama, T., Nakakita, J., Kobayashi, T., Kobayashi, T., Son, J-h., Sakaguchi, H., Leto, T., and Saito, N
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 40693-40705
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[Journal Article] Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ2011
Author(s)
Seki, T., Adachi, N., Abe-Seki, N., Shimahara, T., Takahashi, H., Yamamoto, K., Saito, N. and Sakai, N
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Journal Title
J Pharmacol Sci
Volume: 116
Pages: 239-247
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[Journal Article] Streptococcus mutans diacylglycerol kinase homologue:a potential target for anti-caries chemotherapy2011
Author(s)
Shibata, Y., Kawada-Matsuo, M., Shirai, Y., Saito, N.,Li. D., and Yamashita, Y
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Journal Title
J. Med. Microbiol
Volume: 60
Pages: 625-630
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[Journal Article] Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocytes differentiation2011
Author(s)
Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T., Saito, N
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Journal Title
Mol. Biol. Cell
Volume: 22
Pages: 1340-1352
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[Journal Article] Nuclear Choline Acetyltransferase Activates Transcription of a High-affinity Choline Transporter2011
Author(s)
Matsuo, A., Bellier, J-P, Nishimura, M., Yasuhara, O., Saito, N. and Kimura, H
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 5836-5845
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[Journal Article] Increased seizure susceptibility in a mouse with diacylglycerol kinase β2 deficiency
Author(s)
Ishisaka, M., Tsuruma, K., Shimazawa, M., Shirai, Y.,Saito, N., and Hara, H
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Journal Title
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[Presentation] Role of PKCα-mediated cofilin phosphorylation in the degranulation from RBL-2H3 mast cells2012
Author(s)
Sakuma, M., Shirai, Y., Yoshino, K., Kuramasu, M., Nakamura, T., Mizuno, K., Hide,I., Nakata,Y.and Saito,N
Organizer
22th IUBMB & 37th FEBS
Place of Presentation
スペイン(ポスター発表・英語)
Year and Date
20120904-09
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[Presentation] Glial functions of Rho-family small GTPases during cerebellar development and after CNS injury2012
Author(s)
Ueyama,T., Kondoh T., Kohta M., Kohmura,E., Hayashibe,M., Nakamura,T., Sakahara,M., Kassai,H., Nakao,K., Aiba,A. and Saito,N.
Organizer
14th International congress of histochemistry and cytochemistry
Place of Presentation
京都(ポスター・英語)
Year and Date
20120826-29
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[Presentation] Involvment of PKCgamma in neurodegenerative disease2012
Author(s)
Saito, N., Takahashi, H., Shirafuji, T., Adachi, N., Danno, S., Ueyama, T., Seki, T. and Sakai,N
Organizer
14th International congress of histochemistry and cytochemistry
Place of Presentation
京都(ポスター・英語)
Year and Date
20120826-29
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[Presentation] Novel phosphorylation site(s) of cofilin by PKCα and its negative role in the degranulation from RBL-2H3 mast cells2011
Author(s)
Sakuma,M., Shirai,Y., Yoshino K., Kuramasu,M., Nakamura,T., Mizuno,K., Hide,I., Nakata,Y. and Saito,N
Organizer
he American society for cell biology
Place of Presentation
デンバー(ポスター発表・英語)
Year and Date
20111203-06
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