2012 Fiscal Year Final Research Report
Identification of an inhibitor of mPGES-1 expression and its target molecule
| Project/Area Number |
23659138
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Fumi 九州大学, 大学院・医学研究院, 教授 (50274436)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 新規抗炎症薬 / mPGES-1 |
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| Research Abstract |
We previously found that DIF, synthesized by Dictyostelium discoideum, inhibited the expression of microsomal PGES-1 (mPGES-1).In this study, we tried to identify a new inhibitor of mPGES-1 by natural products library screening and found that niclosamide was more effective than DIF-1. Subsequently, we examined the changes of the gene expression profile induced by DIF-1, DIF-3 and niclosamide using DNA microarray chips. There were several genes affected by all these three compounds, whereas none of them did not seem to be related with inflammation
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