2012 Fiscal Year Final Research Report
Does an endogenous antitussive substance possess any physiologicalrole in living body? : In relation to intractable coughs
| Project/Area Number |
23659139
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAKI Tetsuya 熊本大学, 大学院・生命科学研究部, 准教授 (30264047)
SOEDA Fumio 熊本大学, 大学院・生命科学研究部, 助教 (10336216)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒト血漿タンパク質 / 鎮咳作用 / 難治性咳嗽 / 血液凝固 / 鎮咳薬 / コデイン / モルモット |
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| Research Abstract |
A human coagulation factor XIa (F-XIa) at intravenous dose levels of ng/kg causeda potent antitussive activities on intractable coughs such as coughs occurring inACE-inhibitor treated, sub-acute bronchitic or GERD-like models of guinea pigs. It wassuggested that F-XIa itself may have a potent antitussive activity and that its activitymay be associated with a coagulation activity of F-XIa. In addition, it was suggestedthat the site of action of F-XIa may be in the periphery.
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