2012 Fiscal Year Final Research Report
Disease models using gene expression system in Bombyx mori
| Project/Area Number |
23659144
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ゲノム医化学 |
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| Research Abstract |
We tried to establish gene expression system in Bombyx mori in order to use Bombyx as a model for analyzing human disease. We used specific Bombyx strains which can be infected by AcNPV. After AcNPV containing a target gene (GFP gene) was infected in this specific Bombyx strains, GFP was transiently expressed in Bombyx.
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Research Products
(36 results)
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[Journal Article] Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates proteintranslation.2013
Author(s)
Okumura, F., Okumura, A.J., Uematsu, K., Hatakeyama, S., Zhang, D.E. and Kamura, T
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Journal Title
J Biol Chem
Volume: 288
Pages: 2839-2847
DOI
Peer Reviewed
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[Journal Article] Ymer acts as a multufunctional regulator in NF-kB and Fas signaling pathways2012
Author(s)
Tsukiyama, T., Matsuda-Tsukiyama, M., Bohgaki, M., Terai, S., Tanaka, S. and Hatakeyama, S
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Journal Title
Mol. Med
Volume: 18
Pages: 587-597
DOI
Peer Reviewed
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[Journal Article] TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis2012
Author(s)
Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 12050-12059
DOI
Peer Reviewed
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[Journal Article] TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription2011
Author(s)
Sato, T., Okumura, F., Kano, S., Kondo, T., Ariga, T. and Hatakeyama, S
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Journal Title
J. Cell Sci
Volume: 24
Pages: 3492-3502
DOI
Peer Reviewed
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[Journal Article] TRIM29 negatively regulates p53 via inhibition of Tip602011
Author(s)
Sho, T., Tsukiyama, T., Sato, T., Kondo, T., Cheng, J., Saku, T., Asaka, M. and Hatakeyama, S
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Journal Title
BBA-Mol. Cell Res
Volume: 1813
Pages: 1245-1253
DOI
Peer Reviewed
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[Journal Article] 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitination and cytoplasmic body formation
Author(s)
Ichimura, T., Taoka, M., Shoji, I., Kato, H., ato, T., Hatakeyama, S., Isobe, T. and Hachiya, N
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Journal Title
J. Cell Sci
Volume: (in press)
Peer Reviewed
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[Presentation] ダイオキシン受容体内因性リガンドによる前立腺がん細胞におけるアンドロゲンレセプター発言低下と増殖抑制2012
Author(s)
丸山覚,築山忠維,河津隆文,佐藤択矢,千葉博基,安部崇重,佐澤陽,篠原信雄,畠山鎮次,野々村克也
Organizer
第21回泌尿器科分子・細胞研究会
Place of Presentation
北海道大学医学部学友会館「フラテ」,札幌
Year and Date
20120210-11
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[Presentation] Role of apolipoprotein B100 and oxidized low-density lipoprotein in anti beta2 glycoprotein I induced tissue factor expression on monocytes2011
Author(s)
Otomo K, Atsumi T, Fujieda Y, Nakagawa H, Amengual O, Kato M, Horita T, Tasuda S, Matsumoto M, Hatakeyama, S., Koike T
Organizer
The 75th annual meeting of the American College of Rheumatology
Place of Presentation
Cicago, Illinois
Year and Date
20111105-09
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