2012 Fiscal Year Final Research Report
Role of osteoclasts in metabolic syndrome
| Project/Area Number |
23659149
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHINOHARA Masahiro 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (60345733)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 破骨細胞 / 肥満 / 2型糖尿病 / メタボリックシンドローム |
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| Research Abstract |
Osteoclasts have been believed to be bore-resorbing cells, which play an essential role in bone homeostasis. However, osteoclast-specific conditional knockout mice, which show a severe osteopetrotic phenotype due to a lack of bone-resorbing activity, were resistant to the development of obesity associated with ageing and high fat diet. These results clearly suggested that osteoclasts are involved in the pathogenesis of the obesity, and probably subsequent diabetes.
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[Journal Article] Class IA Phosphatidylinositol 3-kinases regulates osteoclastic bone resorption through Akt-mediated vesicle transport in mice2012
Author(s)
Shinohara M, Nakamura M, Masuda H, Kadono Y, Iwasawa M, Nagase Y, Ueki K, Kadowaki T, Sasaki T, Kato S, Nakamura H, Nakamura K, Tanaka S, Takayanagi H
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 2464-2475
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[Journal Article] TREM2 and -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis2012
Author(s)
Otero K#, Shinohara M#, Zhao H#, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M
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Journal Title
J Immunol
Volume: 188
Pages: 2612-2621
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