Molecular basis for regulation of the cellular life span

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659155
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Kobe University
• Principal Investigator: MATOZAKI Takashi 神戸大学, 医学研究科, 教授 (80252782)
• Co-Investigator(Renkei-kenkyūsha): OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125)
• Project Period (FY): 2011 – 2012
• Keywords: 遺伝子 / シグナル伝達 / 生体分子 / マイクロアレイ / 老化

Research Abstract

Cells constituting organs in the mammals have cell-type-specific life span after their terminal differentiation. The differences in cellular life span are though to be dependent on cell characteristics and functions. However, the molecular basis underlying the regulation of the life span of terminally differentiated cells is not fully elucidated. Moreover, the biological significance of cell-type-specific life span still remains unclear. To clarify the mechanism of the regulation of cellular life span, we performed approaches using mouse intestinal epithelial cells as a model.

Research Products

• [Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment (2013)
  • Author(s): Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, Honma N, Nakao M, Matozaki T, Akashi K
  • Journal Title: Blood Volume: 121 Pages: 1316-1325
  • DOI: DOI:10.1182/blood-2012-06-440354
  • Peer Reviewed
• [Journal Article] Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus (2012)
  • Author(s): Hayashi Y, Kusakari S, Sato-Hashimoto M, Urano E, Shigeno M, Sekijima T, Kotani T, Murata Y, Murakami H, Matozaki T, Ohnishi H
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 428 Pages: 475-481
  • DOI: DOI:10.1016/j.bbrc.2012.10.083
  • Peer Reviewed
• [Journal Article] The Absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons (2012)
  • Author(s): Marschinke F, Hashemian S, Matozaki T, Oldenborg PA, Stromberg I.
  • Journal Title: PloS One Pages: e45218
  • DOI: DOI:10.1371/journal.pone.0045218
  • Peer Reviewed
• [Journal Article] SIRPalpha controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox) (2012)
  • Author(s): van Beek EM, Zarate JA, van Bruggen R, Schornagel K, Tool AT, Matozaki T, Kraal G, Roos D, van den Berg TK
  • Journal Title: Cell Reports Volume: 2 Pages: 748-755
  • DOI: DOI:10.1016/j.celrep.2012.08.027
  • Peer Reviewed
• [Journal Article] Macrophages require Skap2 and Sirpalpha for integrin-stimulated cytoskeletal rearrangement (2012)
  • Author(s): Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD
  • Journal Title: Journal of Cell Science Volume: 125 Pages: 5535-5545
  • DOI: DOI:10.1242/jcs.111260
  • Peer Reviewed
• [Journal Article] SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress (2012)
  • Author(s): Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y, Matozaki T, Ohnishi H, Jiang H, Li H
  • Journal Title: Journal of Neurochemistry Volume: 122 Pages: 834-843
  • DOI: DOI:10.1111/j.1471-4159.2012.07818.x
  • Peer Reviewed
• [Journal Article] Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity (2012)
  • Author(s): Kaneko T, Saito Y, Kotani T, Okazawa H, Iwamura H, Sato-Hashimoto M, Kanazawa Y, Takahashi S, Hiromura K, Kusakari S, Kaneko Y, Murata Y, Ohnishi H, Nojima Y, Takagishi K, Matozaki T
  • Journal Title: Journal of Immunology Volume: 188 Pages: 5397-5407
  • DOI: DOI:10.4049/jimmunol.1103210
  • Peer Reviewed
• [Journal Article] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain. (2012)
  • Author(s): Maruyama T, Kusakari S, Sato-Hashimoto M, Hayashi Y, Kotani T, Murata Y, Okazawa H, Oldenborg PA, Kishi S, Matozaki T, Ohnishi H
  • Journal Title: Journal of Neurochemistry Volume: 121 Pages: 891-902
  • DOI: DOI:10.1111/j.1471-4159.2012.07748.x
  • Peer Reviewed
• [Journal Article] Src family kinases: modulators of neurotransmitter receptor function and behavior (2011)
  • Author(s): Ohnishi H, Murata Y, Okazawa H, Matozaki T
  • Journal Title: Trends in Neurosciences Volume: 34 Pages: 629-637
  • DOI: DOI:10.1016/j.tins.2011.09.005
  • Peer Reviewed
• [Journal Article] CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction (2011)
  • Author(s): ZhaoXW, van Beek EM, Schornagel K, Van der Maaden H, Van Houdt M, Otten MA, Finetti P, Van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F, van den Berg TK
  • Journal Title: Proceedings of the National Academy of Sciences of the United States ofAmerica Volume: 108 Pages: 18342-18347
  • DOI: DOI:10.1073/pnas.1106550108
  • Peer Reviewed
• [Journal Article] SIRPα/CD172a regulates eosinophil homeostasis (2011)
  • Author(s): Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M
  • Journal Title: Journal of Immunology Volume: 187 Pages: 2268-2277
  • DOI: DOI:10.4049/jimmunol.1101008
  • Peer Reviewed
• [Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen (2011)
  • Author(s): Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Mori M, Murata Y, Okazawa H, Ware CF, Oldenborg PA, Nojima Y, Matozaki T
  • Journal Title: Journal of Immunology Volume: 187 Pages: 291-297
  • DOI: DOI:10.4049/jimmunol.1100528
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and its functional roles
  • Author(s): Daniwijaya EW, Murata Y, Kotani T, Kitamura Y, Mantilidewi KI, Kusakari S, Ohnishi H, Okazawa H, Matozaki T
  • Journal Title: Kobe Journal of Medical Sciences
  • Peer Reviewed
• [Presentation] Tyrosine phosphorylation of CEACAM20 and its functional roles (2013)
  • Author(s): Daniwijaya E.W
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 国立がん研究センター(東京)
  • Year and Date: 2013-02-08
• [Presentation] Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1 (2013)
  • Author(s): Murata Y
  • Organizer: 第10回プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 国立がん研究センター(東京)
  • Year and Date: 2013-02-08
• [Presentation] Protein tyrosine phosphatases and the CD47-SIRPα System that mediates cell-to-cell communication (2012)
  • Author(s): Matozaki T
  • Organizer: The First Taiwan Phosphatase Conference
  • Place of Presentation: National Cheng Kung University(台湾・台南)
  • Year and Date: 2012-11-10
• [Presentation] The phosphotyrosine Signaling and its Deregulation in Inflammation and Cancers (2012)
  • Author(s): Matozaki T
  • Organizer: 2nd Bandung Biomolecular Medicine Conference
  • Place of Presentation: Padjadjaran University(インドネシア・バンドン)
  • Year and Date: 2012-10-05
• [Presentation] チロシンホスファターゼの機能と病態 (2012)
  • Author(s): 的崎尚
  • Organizer: 群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」最終シンポジウム
  • Place of Presentation: 群馬大学(群馬)
  • Year and Date: 2012-02-09
• [Presentation] 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1 による腸管免疫制御 (2012)
  • Author(s): 小谷武徳
  • Organizer: 第5回プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2012-01-19
• [Presentation] The R3 subtype of receptor-type protein tyrosine phosphatases: Expression, localization, and biological function (2011)
  • Author(s): Matozaki T
  • Organizer: The First Japan-Taiwan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: 基礎生物学研究所(愛知)
  • Year and Date: 2011-12-02
• [Presentation] A new phosphotyrosine signaling pathway related to autoimmune diseases and cancers (2011)
  • Author(s): Matozaki T
  • Organizer: 2nd International Joint Symposium Frontier In Biomedical Sciences:From Genes to Applications
  • Place of Presentation: Faculty of Medicine, Universitas Gadjah Mada(インドネシア・ジョグジャカルタ)
  • Year and Date: 2011-11-18
• [Presentation] Regulation by protein tyrosine phosphorylation of depression-like behavior Neuroscience (2011)
  • Author(s): 大西浩史
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] チロシンホスファターゼSAP-1 の機能と病態 (2011)
  • Author(s): 岡澤秀樹
  • Organizer: 第10回生体機能研究会
  • Place of Presentation: 清流の郷ブルーヴィラあなぶき(徳島)
  • Year and Date: 2011-07-30
• [Presentation] チロシンホスファターゼの機能と病態 (2011)
  • Author(s): 的崎尚
  • Organizer: 日本生化学会東北支部第77回例会・シンポジウム
  • Place of Presentation: 東北大学さくらホール(宮城)
  • Year and Date: 2011-07-23
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/tougou/signal/Home.html