2012 Fiscal Year Final Research Report
Development of therapy of Alzheimers disease with iPS cell-derivedmacrophages
| Project/Area Number |
23659158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
SENJU Satoru 熊本大学, 大学院・生命科学研究部, 准教授 (50274709)
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| Research Collaborator |
TAKAMATSU Koutaro 熊本大学, 大学院・生命科学研究部, 大学院・・生、医員
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| Project Period (FY) |
2011 – 2012
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| Keywords | アルツハイマー病 / iPS 細胞 / マクロファージ / アミロイドβ |
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| Research Abstract |
The purpose of this study is to generate macrophages with acapacity to degrade or remove amyloid-・protein, which is known to be the causative agentof Alzheimer ’ s disease.Before this project, we had established a technology to generate functionalphagocytes (macrophages) from mouse and human iPS cells. In the current study , wegenerated macrophages expressing Fc-receptor-fused form of single chain antibody specificto amyloid-・. In addition, we made macrophages expressing neprilysin, a protease reportedto be highly potent in degradation of amyloid-・. We administered the genetically modifiediPS cell-derived macrophages into model mice of Alzheimer ’ s disease, and evaluate whetherthey could reduce the level of amyloid-・in vivo.
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