Elucidation of the transcription factor network that regulates cancer-stroma interaction

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659168
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: IGARASHI Kazuhiko 東北大学, 大学院・医学系研究科, 教授 (00250738)
• Project Period (FY): 2011 – 2012
• Keywords: 分子腫瘍学 / 転写因子 / ケモカイン / サイトカイン / Bach1

Research Abstract

Interaction between stroma and cancer cells appears critical for the development of cancer. However, little is known about how the functions of stroma cells are regulated at the level of gene expression. In this project, we focused on the transcription factor Bach1 on which we had several preliminary observations suggesting its important roles in the cancer-stroma interaction. We found that Bach1 is critical for tumor formation in several mouse model systems. We identified downstream genes of Bach1 which appeared to be critical for the stroma function. We also studied the regulation of BACH1 in human stroma cells. These results will be an important foundation for future studies on the cancer-stroma interaction.

Research Products

• [Journal Article] Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12)and maintains ERK signaling (2013)
  • Author(s): Nakanome A, Brydun A, Matsumoto M, Ota K, Funayama R, Nakayama K, Ono M, Shiga K, Kobayashi T, Igarashi K
  • Journal Title: Oncogene Volume: (印刷中)
  • DOI: DOI:(10.1038)
  • Peer Reviewed
• [Journal Article] BTB and CNC Homolog1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-1 (2013)
  • Author(s): Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
  • Journal Title: Inflamm Bowel Disease Volume: 19巻 Pages: 740-753
  • DOI: DOI:(10.1097)
  • Peer Reviewed
• [Journal Article] Bach1 as a regulat or mitosis, beyond its transcriptional function (2012)
  • Author(s): Li J, Shiraki T, Igarashi K
  • Journal Title: Commun Integr Biology Volume: 5巻 Pages: 477-479
  • DOI: DOI:(10.4161)
  • Peer Reviewed
• [Journal Article] Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2 (2012)
  • Author(s): Nishizawa H, Ota K, Dohi Y, Ikura T,Igarashi K
  • Journal Title: Cancer Science Volume: 103巻 Pages: 897-903
  • DOI: DOI:(10.1111)
  • Peer Reviewed
• [Journal Article] Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1 (2011)
  • Author(s): Ota K, Dohi Y, Brydun A, Nakanome A, Ito S, Igarashi K
  • Journal Title: Antioxid Redox Signal Volume: 14巻 Pages: 2441-2451
  • DOI: DOI:(10.1089)
  • Peer Reviewed
• [Presentation] The role of transcription factor Bach1 in cancer-stroma interaction(がんと間質の相互作用における転写因子 Bach1 の意義) (2011)
  • Author(s): BRYDUN ANDREY
  • Organizer: 第34回日本分子生 物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Remarks]
  • URL: http://www.biochem.med.tohoku.ac.jp/