2013 Fiscal Year Final Research Report
Oxygen sensor as a target of type-2 DM treatment
| Project/Area Number |
23659175
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 低酸素 / HIF / PHD / 糖尿病 / インスリン感受性 / インスリン抵抗性 |
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| Research Abstract |
Hypoxic response is mainly regulated by VHL-PHD-HIF pathway. Systemically activating HIF in mice clearly shows blood sugar lowering effect and upregulated insulin sensitivity. Our result would highlight on a new concept of type-II diabetes treatment which target hypoxic response pathway.
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[Journal Article] Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro2013
Author(s)
Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA
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Journal Title
Mol Cancer Res
Volume: 11(9)
Pages: 973-985
Peer Reviewed
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