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2012 Fiscal Year Final Research Report

Identification of molecular target and its therapeutic application for micropapillary adenocarcinoma

Research Project

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Project/Area Number 23659189
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionJichi Medical University

Principal Investigator

NIKI Toshiro  自治医科大学, 医学部, 教授 (90198424)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Daisuke  自治医科大学, 医学部, 助教 (80415554)
Project Period (FY) 2011 – 2012
Keywords肺腺癌
Research Abstract

In this study, we sought to generate in vitro and in vivo model of micropapillary adenocarcinoma by long-term culture on low-binding culture dish. Of the 40 lung adenocarcinoma cell lines, we obseved micropapillary clusters in 24 cell lines.

  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Lung Cancer with Loss of BRG1/BRM, shows Epithelial Mesenchymal Transition Phenotype and Distinct Histologic and Genetic Features.2013

    • Author(s)
      Matsubara D, Niki T (13thof 13)
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 266-273

  • [Journal Article] Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line2012

    • Author(s)
      Matsubara D, Niki T (14thof 14)
    • Journal Title

      LC-2/ad. J Thorac Oncol.

      Volume: 7 Pages: 1872-1876

  • [Journal Article] Epidermal growth factor receptor mutation and chemosensitivity.2012

    • Author(s)
      Matsubara D, Niki T
    • Journal Title

      J Thorac Oncol

      Volume: 4 Pages: 771-772

    • Peer Reviewed
  • [Journal Article] Lung Adenocarcinoma, Mixed Subtype: Histopathologic Basis for High-Resolution Computed Tomography Findings.2011

    • Author(s)
      Terasaki H, Niki T (5thof 8)
    • Journal Title

      J Thorac Imaging

      Volume: 26 Pages: 74-81

    • Peer Reviewed
  • [Journal Article] Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases.2011

    • Author(s)
      Goto A, Niki T (4thof 17)
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 1383-1390

    • Peer Reviewed
  • [Presentation] KRAS 変異,EMT 形質を有する肺腺癌細胞の薬剤感受性2012

    • Author(s)
      仁木 利郎、松原 大祐、石川 俊平、A BC DAB深山 正久
    • Organizer
      第53回日本肺癌学会総会
    • Place of Presentation
      岡山
    • Year and Date
      20121108-09
  • [Presentation] 原発性肺腺癌におけるクロマチンリモデリング因子 BRG1 及び BRMの欠損と上皮間葉系転換との関連性について.2012

    • Author(s)
      松原 大祐、喜舎場由香、石川 俊平、村上 善則、油谷 浩幸、深山 正久、仁木 利郎
    • Organizer
      第53回日本肺癌学会総会
    • Place of Presentation
      岡山
    • Year and Date
      20121108-09
  • [Presentation] 肺腺癌における Snail の発現についての免疫組織学的検討2012

    • Author(s)
      喜舎場由香, 松原大祐, 仁木利郎
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      20120426-28
  • [Presentation] Histopathologic and genetic features of lung adenocarcinomas with loss of chromatin remodeling factors, BRG-1 and BRM.2012

    • Author(s)
      Matsubara D, Niki T (5th of 5)
    • Organizer
      Annual Meeting of American Association for Cancer Research (poster presentation)
    • Place of Presentation
      Chicago
    • Year and Date
      20120000
  • [Presentation] 一般示説(病理):肺腺癌症例の気管支上皮マーカーの発現に基づく分類:組織学的形態、遺伝子異常、 EGFR,METの活性化との関連.2011

    • Author(s)
      松原大祐, 石川俊平,深山正久,仁木利郎
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      20111103-04
  • [Presentation] 肺腺癌細胞株の遺伝子発現データに基づく分類と、 3 次元培養下の細胞形態、遺伝子異常の関連性について.2011

    • Author(s)
      松原大祐,石川俊平,深山正久,仁木利郎
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      東京,ポスター発表
    • Year and Date
      20110428-30
  • [Presentation] Expressions of bronchial epithelial markers correlate with morphology and genetic abnormalities in lung adenocarcinoma.2011

    • Author(s)
      Matsubara D, Niki T (4th of 4)
    • Organizer
      70th Annual Meeting of the Japanese Cancer Association (poster presentation)
    • Place of Presentation
      Nagoya
    • Year and Date
      20110000
  • [Presentation] Three dimensional culture reveals genetic-morphologic correlations that may be relevant to classification of lung adenocarcinomas.2011

    • Author(s)
      Niki T, Matsubara D, Ishikawa S, Fukayama M
    • Organizer
      14th World Conference of Lung Cancer (poster presentation)
    • Place of Presentation
      Amsterdam
    • Year and Date
      20110000
  • [Presentation] Lung adenocarcinomas show genetic-morphologic correlations in three dimensional culture.2011

    • Author(s)
      Matsubara D, Niki T (4th of 4)
    • Organizer
      Annual Meeting of American Association for Cancer Research (poster presentation)
    • Place of Presentation
      Orlando
    • Year and Date
      20110000
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/pathol/

URL: 

Published: 2014-08-29   Modified: 2014-10-07  

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