2012 Fiscal Year Final Research Report
Analysis of the regulatory mechanism of IL-17/IL-22 production during bacterial infection
| Project/Area Number |
23659200
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo (2012)
Tokyo Medical and Dental University (2011) |
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Principal Investigator |
OKAMOTO Kazuo 東京大学, 大学院・医学系研究科, 助教 (00436643)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 炎症 / 免疫学 / サイトカイン |
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| Research Abstract |
To clarify the regulatory mechanism of IL-17 and IL-22 production in response to bacterial infection, we analyzed the spatio-temporal behavior of Th17 cells and IL-17/IL-22-producing innate lymphoid cells during bacterial infection, using the reporter mice for visualization of Th17-related cytokine. Furthermore, we performed transcriptome analyses of IL-17-producing cells and IL-22-producing cells, and explored the factors which may regulate the expression of IL-22 in Th17 cells or IL-17/IL-22-producing innate lymphoid cells.
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