2012 Fiscal Year Final Research Report
Identification of Helicobacter pylori-derived ncRNAs that induce host response disruption
| Project/Area Number |
23659220
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MIMURO Hitomi 東京大学, 医科学研究所, 准教授 (80396887)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Fumito 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (30423122)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 細菌 / 感染症 / ヘリコバクターピロリ |
|---|
| Research Abstract |
The aim of this study was to explore effector RNAs in Helicobacter pylori, which disrupt host responses. In silico analysis revealed that there is no effector RNAs possessing human microRNA-like conformation in H. pylori genome sequence. We found that the levels of several microRNAs were increased independent of the bacterial RNA transfer in H. pylori-infected epithelial cells. The effect of the identified microRNA increased in H. pylori-infected cells was estimated as the cell proliferation of host cells.
|
