2012 Fiscal Year Final Research Report

Development of the molecular imaging agent for the diagnostic imaging of a deep mycosis and a bacterial infectious disease

Research Project

Project/Area Number	23659221
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Bacteriology (including Mycology)
Research Institution	University of Fukui
Principal Investigator	NORIKI Sakon 福井大学, 医学部, 准教授 (30228374)
Co-Investigator(Renkei-kenkyūsha)	INAI Kunihiro 福井大学, 医学部, 助教 (30313745) KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603) IDO Tatsuo 福井大学, 高エネルギー医学研究センター, 客員教授 (80134063)
Project Period (FY)	2011 – 2012
Keywords	診断
Research Abstract	We synthesized N-[18F]Fluoroacetyl-D- glucosamine (18F-GlcNAc: FAG), As a molecular imaging agent specifically taken into the fungus and bacteria.We proved that we can specifically image the infection nest in the living body by FAG-PET for the rats with bacterial infection and noninfectious inflammation. Moreover, we confirmed the curative effects of antibiotic by time-dependent changes of FAG-PET images of the infection rat medicated with the antibiotic.Furthermore, I newly compounded two kinds of precursor for FAG synthesis, and have improved yield of FAG