2013 Fiscal Year Final Research Report

Establish of a mouse model of encephalopathy after Salmonella gastroenteritis

Research Project

Project/Area Number	23659224
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Bacteriology (including Mycology)
Research Institution	Nara Medical University
Principal Investigator	MIZUNO Fumiko 奈良県立医科大学, 医学部, 講師 (70271202)
Project Period (FY)	2011 – 2013
Keywords	サルモネラ胃腸炎後脳症 / マウスモデル / L form / 脳内ｻｲﾄｶｲﾝ
Research Abstract	We attempted to make a mouse model for Salmonella encephalopathy after acute Salmonella gastroenteritis. We used Salmonella typhimurium SPI2-(Salmonella pathogenicity island 2 deficiency strain),which colonized at the intestine and rarely translocated to reticuloendothelial system, and used C57BL/6 mice which were susceptible to Salmonella. Infected mice didn't show neurological signs. In some cases bacillary form of Salmonella was recovered from spleen and liver. In other cases L-form not bacillary form Salmonella was recovered from brain, simultaneously the message of TNF-alpha from brain was expressed and inflammatory cells were accumulated in the cerebral cortex.

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