2012 Fiscal Year Final Research Report
Functional Analysis of Influenza Virus RNA Polymerase usingcompound libraries
| Project/Area Number |
23659227
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
WAKAI Chitose 筑波大学, 医学医療系, 研究員 (00383662)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 化合物ライブラリー / インフルエンザウイルス / RNA依存RNAポリメラーゼ / In silico解析 / 抗ウイルス薬 / 分子生物学 / ゲノム複製 |
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| Research Abstract |
From compound libraries, we tried to isolate the candidate compounds which inhibit the function of influenza virus RNA polymerase and to clarify how they inhibit the polymerase using a chemical biology approach. We screened the libraries containing 3 million compounds by in silico analysis and the inhibitory effect on infection. Finally, we succeeded to isolate candidate compounds and the mutant viruses against them. Now, we are analyzing the function of mutations in more detail.
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