• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Systembiology of T-cell differentiation

Research Project

  • PDF
Project/Area Number 23659242
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKeio University

Principal Investigator

YOSHIMURA Akihiko  慶應義塾大学, 医学部, 教授 (90182815)

Co-Investigator(Renkei-kenkyūsha) YAMADA Satoshi  岡山理科大学, 工学部, 教授 (20393506)
Project Period (FY) 2011 – 2012
Keywordsサイトカイン シグナル伝達 / 転写因子 / ヘルパーT細胞 / 抑制性T細胞 / TGF-β / シミュレーション
Research Abstract

Helper T cells have been thought to play a central role in not only acquired immune responses but also inimmune regulation. Recently, several subsets such as Th17 and iTreg have been discovered in addition toTh1 and Th2. Differentiation of each helper T c

  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis2013

    • Author(s)
      Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A
    • Journal Title

      Nature Immunol

      Volume: 14(3) Pages: 230-7

    • Peer Reviewed
  • [Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization2013

    • Author(s)
      Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A
    • Journal Title

      J Immunol

      Volume: 190(4) Pages: 1778-87

    • Peer Reviewed
  • [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012

    • Author(s)
      Shichita T, Hasegawa E, Kimura A, MoritaR, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, and Yoshimura A
    • Journal Title

      Nature Medicine

      Volume: 18(6) Pages: 977-7

    • Peer Reviewed
  • [Journal Article] Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi)2012

    • Author(s)
      Yoshida H, Suzuki M, Sakaguchi R, Tani I, Kotani H, Shudo N, Yoshimura A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 422(1) Pages: 174-80

    • Peer Reviewed
  • [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways.2012

    • Author(s)
      Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A
    • Journal Title

      Int Immunol

      Volume: 24(4) Pages: 253-65

    • Peer Reviewed
  • [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.2012

    • Author(s)
      Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418(2) Pages: 234-40

    • Peer Reviewed
  • [Journal Article] Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.2011

    • Author(s)
      Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A
    • Journal Title

      J Immunol

      Volume: 187(9) Pages: 4611-20

    • Peer Reviewed
  • [Journal Article] IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.2011

    • Author(s)
      Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
    • Journal Title

      Int Immunol

      Volume: 23(11) Pages: 701-12

    • Peer Reviewed
  • [Journal Article] Histone 3 lysine 9 (H3K methyltransferase recruitment to the interleukin-2 (IL- promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.2011

    • Author(s)
      Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A
    • Journal Title

      J Biol Chem

      Volume: 286(41) Pages: 35456-65

    • Peer Reviewed
  • [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin2011

    • Author(s)
      Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
    • Journal Title

      Immunity

      Volume: 34(5) Pages: 741-54

    • Peer Reviewed
  • [Journal Article] Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma2011

    • Author(s)
      Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404(1) Pages: 261-7

    • Peer Reviewed
  • [Presentation] Sensitivity analysis of helper T cell differentiation2012

    • Author(s)
      Satoshi Yamada, Akihiko Yoshimura
    • Organizer
      第41回日本免疫学会 学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
  • [Presentation] Sensitivity analysis of computer model of helper T cell differentiation2012

    • Author(s)
      Satoshi Yamada, Akihiko Yoshimura
    • Organizer
      The 3rd Synthetic Immunology Workshop
    • Place of Presentation
      京都
    • Year and Date
      2012-05-19
  • [Presentation] Important factors in computer model of helper T cell differentiation2011

    • Author(s)
      Satoshi Yamada, Akihiko Yoshimura
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
  • [Remarks]

    • URL

      http://new.immunoreg.jp/

URL: 

Published: 2014-08-29   Modified: 2014-10-07  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi