2012 Fiscal Year Final Research Report
Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
| Project/Area Number |
23659247
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Toyama Prefectural Institute. for Pharmaceutical Research. |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 准教授 (30431761)
MATSUNAGA Takayuki 富山県薬事研究所, 主幹研究員 (30121289)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | アレルギー / 免疫関連疾患 |
|---|
| Research Abstract |
(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.
|
-
-
[Journal Article] The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.2012
Author(s)
Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y
-
Journal Title
Diabetes
Volume: 61
Pages: 1199-1209
DOI
Peer Reviewed
-
-
[Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.2012
Author(s)
Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K
-
Journal Title
J. Immunol.
Volume: 188
Pages: 703-713
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
