2012 Fiscal Year Final Research Report
Establishment of model mice of systemic inflammatory response syndrome associated with multiple organ dysfunction syndrome, and investigation of associated with multiple organ dysfunction syndrome, and investigation of
| Project/Area Number |
23659280
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ファーマコゲノミックス |
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| Research Abstract |
To put the molecular mechanism for pathogenesis of systemicinflammatory response syndrome (SIRS) to practical use, the following studies wereperformed. (1) Focusing on p38 which plays a central role in various inflammatoryresponses, one of mitogen-activated protein kinase (MAPK), we tried to produce transgenicmice exhibiting systemic p38 activation in a tetracycline-dependent manner. (2) Weproduced a new model mouse of sepsis in place of the cecal ligation and puncture, oneof SIRS models. Then, we investigated its reliability.
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[Journal Article] Mechanism for p38α-mediated experimental2012
Author(s)
Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, SakairiA, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A and Kasuya Y
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Journal Title
J. Biol. Chem.
Volume: Vol.287
Pages: 24228-24238
DOI
Peer Reviewed
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[Journal Article] Role2012
Author(s)
Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Matsunaga F, Iwamura C, Nakayama T and Tatsumi K
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Journal Title
L i f e S c i .
Volume: Vol.90
Pages: 657-665
DOI
Peer Reviewed
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