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2013 Fiscal Year Final Research Report

Translational research of phama and food by greentea

Research Project

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Project/Area Number 23659287
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionUniversity of Shizuoka

Principal Investigator

YAMADA Shizuo  静岡県立大学, 薬学部, 教授 (80106434)

Co-Investigator(Renkei-kenkyūsha) WATANABE Hiroshi  浜松医科大学, 医学部, 教授 (50262803)
Project Period (FY) 2011 – 2012
Keywords緑茶 / カテキン類 / シンバスタチン / 相互作用
Research Abstract

The present study aimed to evaluate the effect of catechin-rich green tea consumption on the pharmacokinetics of simvastatin lactone (SIM) and simvastatin acid (SVA). A single oral dose of SIM was administered to healthy Japanese male volunteers after drinking of green tea or water for 2 weeks. Blood samples were collected up to 24 h after the administration. Plasma concentrations of SIM and SVA were determined. Pharmacokinetic parameters were estimated by non-compartmental analysis. Chronic consumption of catechin-rich green tea increased the area under the plasma concentration-time curve (AUC) and maximum concentration (Cmax) of SIM. It also inhibited CYP enzymes in the liver. Thus, the chronic consumption of catechin-rich green tea may cause the clinically relevant interaction with simvastatin.

  • Research Products

    (7 results)

All 2013 2012 2011

All Journal Article (4 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Effects of green tea extracts and (-)-epiga llocatechin 3-gallae on pharmacokinetics of nadolol in rats2013

    • Author(s)
      Shingen Misaka, N Miyazaki, T Fukushi ma, Shizuo Yamada and Junko Kimura
    • Journal Title

      Phytomedicine

      Volume: 20 Pages: 1247-1250

  • [Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013

    • Author(s)
      Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
    • Journal Title

      Drug Metab. Pharmacokinet

      Volume: 28 Pages: 244-9

  • [Journal Article] Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS2013

    • Author(s)
      Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Sekihiro Tamaki, Jose P. Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
    • Journal Title

      Biomed.Chromatogr

      Volume: 27 Pages: 1-6

  • [Journal Article] Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS2012

    • Author(s)
      Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
    • Journal Title

      Biomed. Chromatogr

      Volume: 27 Pages: 1-6

  • [Presentation] ヒト臓器由来ミクロソームを用いた CYP2B6, CYP2C8, CYP2C19 および CYP3A 活性に対する緑茶カテキン類の阻害効果2011

    • Author(s)
      川邉 圭佑、三坂 眞元、尾上 誠良、山田静雄
    • Organizer
      第9回日本機能性食品医用学会総会 (要旨集 p.137)
    • Place of Presentation
      大阪
    • Year and Date
      2011-12-11
  • [Presentation] 健常人における臨床薬の体内動態に及ぼすカテキン類高含有緑茶の影響2011

    • Author(s)
      川邉 圭佑、三坂 眞元、竹内 和彦、田邉健樹、小佐野 郁香、乾 直輝、尾上 誠良、Jose P. Werba、木村 純子、渡邉 裕司、山田 静雄
    • Organizer
      第32回日本臨床薬理学会 (講演要旨集 p.S271)
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
  • [Book] 第2章 食品の機能と薬物.第2節 薬物と栄養の相互作用. 国民栄養白書 2012年版 (中村丁次、門脇 孝 監修)(vol 20)2012

    • Author(s)
      山田静雄、木苗直秀
    • Total Pages
      76-84
    • Publisher
      (株)日本医療企画

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Published: 2015-06-25  

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