2013 Fiscal Year Final Research Report
Translational research of phama and food by greentea
| Project/Area Number |
23659287
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
YAMADA Shizuo 静岡県立大学, 薬学部, 教授 (80106434)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 緑茶 / カテキン類 / シンバスタチン / 相互作用 |
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| Research Abstract |
The present study aimed to evaluate the effect of catechin-rich green tea consumption on the pharmacokinetics of simvastatin lactone (SIM) and simvastatin acid (SVA). A single oral dose of SIM was administered to healthy Japanese male volunteers after drinking of green tea or water for 2 weeks. Blood samples were collected up to 24 h after the administration. Plasma concentrations of SIM and SVA were determined. Pharmacokinetic parameters were estimated by non-compartmental analysis. Chronic consumption of catechin-rich green tea increased the area under the plasma concentration-time curve (AUC) and maximum concentration (Cmax) of SIM. It also inhibited CYP enzymes in the liver. Thus, the chronic consumption of catechin-rich green tea may cause the clinically relevant interaction with simvastatin.
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[Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013
Author(s)
Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
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Journal Title
Drug Metab. Pharmacokinet
Volume: 28
Pages: 244-9
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