2012 Fiscal Year Final Research Report
Establishment of a strategy for the detection of disease-related modification of proteins in serum
| Project/Area Number |
23659305
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
KODERA Yoshio 北里大学, 理学部物理学科, 准教授 (60265733)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEDA Tadakazu 北里大学, 名誉教授 (90265728)
NOMURA Fumio 千葉大学, 医学研究院, 教授 (80164739)
GOJIMA Naoki (独)産業技術総合研究所生物情報解析研究センター, 主任研究員 (70215482)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 臨床検査医学 / 血中診断マーカー |
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| Research Abstract |
Modifications of protein such as post-translational modification, cleavage and alternative splicing are caused by disease. In this study, we have developed the strategy to detect disease-related protein modification in serum.
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[Journal Article] Establishment and application of a high-quality comparative analysis strategy for the discovery and small-scale validation of low-abundance biomarker peptides in serum based on an optimized novel peptide extraction method2013
Author(s)
Saito T, Kawashima Y, Minamida M, Matsumoto K, Araki K, Matsui T, Satoh M, Nomura F, Iwamura M, Maeda M, Baba S, Kodera Y
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Journal Title
J. Electrophoresis
Volume: 57
Pages: 1-9
DOI
Peer Reviewed
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[Journal Article] Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease2013
Author(s)
Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y,Matsushita K, Izumi Y, Nomura F
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Journal Title
Peer Reviewed
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[Journal Article] Oryziaslatipes, as a model for human obesity-related glomerulopathy2013
Author(s)
Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I,Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T. Medaka
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Journal Title
Biochem Biophys Res Commun
Volume: 431(4)
Pages: 712-7
Peer Reviewed
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[Journal Article] Integrated view of the humanchromosome X-centric proteome project2013
Author(s)
Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T,Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N
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Journal Title
J Proteome Res
Volume: 12(1)
Pages: 58-61
Peer Reviewed
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[Journal Article] Angiotensin-converting enzymeinhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortexduring the early stage of diabetes mellitus in rats2013
Author(s)
Ishii N, Carmines PK, Yokoba M, Imaizumi H, Ichikawa T, Ikenagasa H, Kodera Y,Oh-Ishi M, Aoki Y, Maeda T, Takenaka T, Katagiri M
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Journal Title
Clin Sci (Lond)
Volume: 124(8)
Pages: 543-52
Peer Reviewed
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[Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples2012
Author(s)
Narumi R, Murakami T, Kuga T, Adachi J, Shiromizu T, Muraoka S, Kume H, Kodera Y, Matsumoto M, Nakayama K, Miyamoto Y, Ishitobi M, Inaji H, Kato K, Tomonaga T
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Journal Title
J Proteome Res
Volume: 11(11)
Pages: 5311-22
Peer Reviewed
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[Journal Article] Strategy for SRM-basedverification of biomarker candidates discovered by iTRAQ method in limited breast cancer tissue samples2012
Author(s)
Muraoka S, Kume H, Watanabe S, Adachi J, Kuwano M, Sato M, Kawasaki N, Kodera Y,Ishitobi M, Inaji H, Miyamoto Y, Kato K, Tomonaga T
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Journal Title
J Proteome Res
Volume: 11(8)
Pages: 4201-10
Peer Reviewed
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[Journal Article] Proteomic analysis of gingivalcrevicular fluid for discovery of novel periodontal disease markers2012
Author(s)
Tsuchida S, Satoh M, Umemura H, Sogawa K, Kawashima Y, Kado S, Sawai S,Nishimura M, Kodera Y, Matsushita K, Nomura F
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Journal Title
Proteomics
Volume: 12(13)
Pages: 2190-202
Peer Reviewed
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