2013 Fiscal Year Final Research Report
Identification of frog cutaneous nociceptors and functional analysis of them using transgenic flies
| Project/Area Number |
23659321
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Shigeru 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 細胞生理学研究部, 助教 (50422069)
ISONO Kunio 東北大学, (連合)農学研究科(研究院), 産学連携研究員 (70124550)
MASUZAWA Toru 茨城大学, 工学部, 教授 (40199691)
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| Co-Investigator(Renkei-kenkyūsha) |
YONEHARA Norifumi 奥羽大学, 歯学部, 教授 (70124534)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 機械性侵害受容体 / ショウジョウバエ / カエル / TRPV1 / TRPV4 |
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| Research Abstract |
In this study, it was revealed that capsaicin induces mechanical allodinia but does not induce thermal allodinia in frog. It was suggested that ATP-P2X system might play an important role in induction of mechanical allodinia in frog, because P2X antagonist suramine blocked capsaicin-induced mechanical allodinia. We devised the nano oscillating impression equipment which used the elastic hinge mechanism to apply minute mechanical stimulation for taste organs (taste hairs) of the fly.
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[Journal Article]2012
Author(s)
Adachi R, Sasaki Y, Morita H, Komai M, Shirakawa H, Goto T, Furuyama A, Isono K
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Journal Title
J Neurogenet
Volume: 26
Pages: 198-205
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[Presentation]2012
Author(s)
古山昭、大須賀謙二、米原典史、宗形芳英
Organizer
第54回歯科基礎医学会学術大会
Place of Presentation
郡山
Year and Date
20120914-16
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