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2012 Fiscal Year Final Research Report

Roles of microRNA in inflammation-related carcinogenesis and its possibility for use as a biomarker

Research Project

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Project/Area Number 23659327
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

MURATA Mariko  三重大学, 大学院・医学系研究科, 教授 (10171141)

Co-Investigator(Kenkyū-buntansha) MIDORIKAWA Kaoru  三重大学, 大学院・医学系研究科, リサーチアソシエイト (20393366)
Project Period (FY) 2011 – 2012
Keywords炎症 / 上咽頭癌 / microRNA / ターゲット遺伝子 / バイオマーカー
Research Abstract

Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is one of the inflammation-associated cancers. To explore the mechanisms of NPC development and certain biomarkers for screening, a microarray profiling survey was performed to reveal the expression patterns of microRNAs across primary tumors (NPC) and normal nasopharyngeal epithelia (NNE). Quantitative real-time PCR confirmed that expression levels of the microRNAs were significantly different between NPC and NNE tissues. Several microRNAs also have significant differences in plasma samples. Up- and down-regulated microRNAs may play a role in NPC development and there is a possibility to use as biomarkers and novel targets for NPC treatment.

  • Research Products

    (37 results)

All 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (22 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma2012

    • Author(s)
      Mo Y, Midorikawa K, Zhang Z, Zhou X, Ma N, Huang G, Hiraku Y, Oikawa S, Murata M
    • Journal Title

      Cancer Lett

      Volume: 323(2) Pages: 147-54

    • Peer Reviewed
  • [Journal Article] Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis2012

    • Author(s)
      Murata M, Thanan R, Ma N, Kawanishi S
    • Journal Title

      J Biomed Biotechnol

      Pages: 623019

    • Peer Reviewed
  • [Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression2012

    • Author(s)
      Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, . 2012:623019. (2012). 査読有Murata M, Kawanishi S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421(2) Pages: 280-5

    • Peer Reviewed
  • [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma2012

    • Author(s)
      Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
    • Journal Title

      Free Radic. Biol Med.

      Volume: 52(8) Pages: 52(8)

    • Peer Reviewed
  • [Journal Article] Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer2012

    • Author(s)
      Thanan R, Murata M, Ma N, Hiraku Y., Oikawa S, Hammam O, Wishahi M, El Leithy T, Kawanishi S
    • Journal Title

      Mediat. Inflamm

      Pages: 165879

    • Peer Reviewed
  • [Journal Article] Proton pump inhibitors suppress iNOS-dependentDNA damage in Barrett's esophagus by increasing Mn-SOD expression2012

    • Author(s)
      Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 421 Pages: 280-285

    • Peer Reviewed
  • [Journal Article] CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure2012

    • Author(s)
      Huang S, Guo S, Guo F, Yang Q, Xiao X, Murata M, Ohnishi S, Kawanishi S, Ma N
    • Journal Title

      Eur. J. Histochem

    • Peer Reviewed
  • [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells2012

    • Author(s)
      Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y
    • Journal Title

      Toxicol. Appl. Pharmacol

      Volume: 260(2) Pages: 183-92

    • Peer Reviewed
  • [Journal Article] Mechanisms of oxidative DNA damage induced by carcinogenic arylamines2011

    • Author(s)
      Murata M, Kawanishi S.
    • Journal Title

      Front Biosci

      Volume: 1(16) Pages: 1132-43

    • Peer Reviewed
  • [Journal Article] Nitrative and oxidative DNA damage caused by K-ras mutation in mice. Biochem. Biophys2011

    • Author(s)
      Ohnishi S, Saito H, Suzuki N, Ma N, Hiraku Y, Murata M., Kawanishi, S
    • Journal Title

      Res. Commun

      Volume: 413 Pages: 236-240

    • Peer Reviewed
  • [Journal Article] Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma2011

    • Author(s)
      Huang Y-J, Zhang B-B, Ma N, Murata M,Tang A-Z, Huang G-W
    • Journal Title

      Med Oncol

      Volume: 28 Pages: 377-84

    • Peer Reviewed
  • [Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection2011

    • Author(s)
      Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, Leithy TE, Hiraku Y, Amro el K, Oikawa S, Ohnishi S,Murata M,Kawanishi S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 414 Pages: 344-349

    • Peer Reviewed
  • [Journal Article] Astrocytic neuroprotection through induction of cytoprotective molecules; a proteomic analysis of mutant P301S tau-transgenic mouse2011

    • Author(s)
      Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H
    • Journal Title

      Brain Res

      Volume: 1410 Pages: 12-23

    • Peer Reviewed
  • [Presentation] 多層カーボンナノチューブによるDNA損傷:肺上皮細胞における8-ニトログアニン生成2013

    • Author(s)
      平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくば市
    • Year and Date
      20130201-02
  • [Presentation] 上咽頭癌におけるmicroRNA調節異常の検討2012

    • Author(s)
      王淑民、莫穎禧、翠川薫、張哲、黄光武、馬寧、平工雄介、及川伸二, 村田真理子
    • Organizer
      第41回日本環境変異原学会
    • Place of Presentation
      静岡市
    • Year and Date
      20121129-30
  • [Presentation] ビルハルツ住血吸虫感染による膀胱癌におけるDNA損傷と幹細胞マーカー2012

    • Author(s)
      大西志保、馬寧、タナン レイヌー、小林 果、平工雄介、及川伸二、村田真理子、川西正祐
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋市
    • Year and Date
      20121025-26
  • [Presentation] バレット食道におけるプロトンポンプ阻害剤のMn-SOD発現を介したDNA損傷への効果2012

    • Author(s)
      村田真理子,平工雄介,及川伸二,タナン レイヌー,ピラオール ソムチャイ,馬寧,川西正祐
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋市
    • Year and Date
      20121025-26
  • [Presentation] カーボンナノチューブによる細胞内ニトロ化DNA損傷2012

    • Author(s)
      平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋市
    • Year and Date
      20121025-26
  • [Presentation] Association of asbestos fiber contents with oxidative and nitrative DNA damage in human lung2012

    • Author(s)
      平工雄介、馬寧、川西正祐、村田真理子
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      20120919-21
  • [Presentation] Genome-wide DNA methylation study of nasopharyngeal carcinoma in Chinese patients with Epstein-Barr virus infection2012

    • Author(s)
      Yingxi Mo, Kaoru Midorikawa, Ning Ma, Xiaoying Zhou, Guangwu Huang, Zhe Zhang, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      20120919-21
  • [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube with different lengths in cultured cells2012

    • Author(s)
      Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      20120919-21
  • [Presentation] Stromal expression of alpha-smooth muscle actin correlates with SDF-1 in nasopharyngeal carcinoma2012

    • Author(s)
      Shumin Wang, Ning Ma, Shosuke Kawanishi, Yusuke Hiraku, Shinji Oikawa, Ying Xie, Zhe Zhang, Guangwu Huang, Mariko Murata
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      20120919-21
  • [Presentation] 食品中に含まれる有効成分の安全性評価:酸化促進作用によるDNA損傷性とエストロゲン感受性乳癌細胞の増殖促進作用2012

    • Author(s)
      大西志保、村田真理子、川西正祐
    • Organizer
      日本社会薬学会第31年会
    • Place of Presentation
      鈴 鹿市
    • Year and Date
      20120915-16
  • [Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress. The 7th International Conference on the Biology2012

    • Author(s)
      Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi, Mariko Murata
    • Organizer
      Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      20120722-26
  • [Presentation] Nitrative DNA damage in human lung tissues in association with asbestos exposure. The 7th International Conference on the Biology2012

    • Author(s)
      Yusuke Hiraku, Kiyoshi Sakai, Eiji Shibata, Michihiro Kamijima, Naomi Hisanaga, Ning Ma, Shosuke Kawanishi, Mariko Murata
    • Organizer
      Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      20120722-26
  • [Presentation] Arsenic-induced nitrative DNA damage in human HaCaT kerationcytes. The 7th International Conference on the Biology2012

    • Author(s)
      Ning Ma, Shiwen Huang, Feiye Guo, Songchao Guo, Mariko Murata, Shosuke Kawanishi
    • Organizer
      Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      20120722-26
  • [Presentation] Nitrative DNA damage in human lung epithelial cells treated with multi-walled carbon nanotube. The 7th International Conference on the Biology2012

    • Author(s)
      Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
    • Organizer
      Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      20120722-26
  • [Presentation] シンポジウム2健康長寿社会における学会活動の方向性、がんとエピジェネティクス2012

    • Author(s)
      村田真理子
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      20120324-26
  • [Presentation] Melatonin protects against Opisthorchis viverrini-associated cholangiocarcinoma and liver injury in hamsters2012

    • Author(s)
      Umawadee Laothong, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Somchai Pinlaor
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      20120324-26
  • [Presentation] Identification of dysregulated microRNA in nasopharyngeal carcinoma2012

    • Author(s)
      Shumin Wang, Yingxi Mo, KaoruMidorikawa, Zhe Zhang, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      20120324-26
  • [Presentation] Up-regulation of GLRX3 is associated with invasion and metastasis in nasopharyngeal carcinoma2012

    • Author(s)
      Bo Hou, Yingxi Mo, Zhe Zhang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Kaoru Midorikawa, Mariko Murata
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      20120324-26
  • [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube in cultured cells: a comparison with oxidative DNA damage2012

    • Author(s)
      Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
    • Organizer
      第83回日本衛生学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      20120324-26
  • [Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis2012

    • Author(s)
      Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi, Mariko Murata
    • Organizer
      Mahidol International Conference on Infection and Cancer
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20120206-08
  • [Presentation] Parasite infection induces oxidative/nitrative DNA damage in stem-like cells in relation to carcinogenesis2011

    • Author(s)
      Raynoo Thanan, Mariko Murata, Ning Ma,Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      20111003-05
  • [Presentation] 乳癌治療薬タモキシフェンによる子宮内膜発がん機構の検討2011

    • Author(s)
      中村朱里、翠川薫、平工雄介、及川伸二、福原潔、川西正祐、村田真理子
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      20110325-28
  • [Book] 8-Nitroguanine: A potential biomarker to evaluate the risk of inflammation-related carcinogenesis2012

    • Author(s)
      Ma N, Murata M, Ohnishi S, Thanan R, Hiraku Y, Kawanishi S
    • Total Pages
      201-224
    • Publisher
      Biomarker. Khan TK
  • [Remarks]

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

URL: 

Published: 2014-09-25   Modified: 2015-09-15  

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