2012 Fiscal Year Final Research Report
Risk assessment of fibrous and particulate matters on the basis of microRNomics
| Project/Area Number |
23659328
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 繊維・粒子状物質 / マイクロRNA / 石綿 / シリカ / 黄砂 / カーボンナノチューブ / マイクロアレイ / リスク評価 |
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| Research Abstract |
Fibrous and particulate matters cause inflammation in respiratory systems, leading to carcinogenesis and fibrosis. It is necessary to establish the system to evaluate the risk of these matters. microRNA (miRNA) is expected as a potential biomarker for various human diseases. In this study, we found that the expression of some miRNAs was significantly changed in the lung of mice exposed to asbestos, Asian dust and silica. These results suggest that miRNA can be used as a biomarker to evaluate the risk of these matters.
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Research Products
(24 results)
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[Journal Article] Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma2012
Author(s)
Prakobwong S, Charoensuk L, Hiraku Y, Pinlaor P, Pairojkul C, Mairiang E, Sithithaworn P, Yongvanit P, Khuntikeo N, Pinlaor S
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Journal Title
Int. J. Cancer
Volume: 131
Pages: E416-424
DOI
Peer Reviewed
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[Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma2012
Author(s)
Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
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Journal Title
Free. Radic. Biol. Med
Volume: 52
Pages: 1465-1472
DOI
Peer Reviewed
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[Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection2011
Author(s)
Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, Leithy TE, Hiraku Y, Amro el K, Oikawa S, Ohnishi S, Murata M, Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 414
Pages: 344-349
DOI
Peer Reviewed
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