2012 Fiscal Year Final Research Report
Basic study on the effects of arsenic on higher brain functions
| Project/Area Number |
23659332
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MADHYASTHA Harishkumar 宮崎大学, 医学部, 助教 (00543951)
WAKAZONO Yoshihiko 宮崎大学, 医学部, 助教 (90377755)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒ素 / 高次脳機能 / シナプス可塑性 |
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| Research Abstract |
It is known that the arsenic toxicities consist of acute andchronic effects. Recently the chronic arsenic exposure causes critical health problemfor people who drink ground water containing arsenic in many countries of South Asia.One of well-known chronic toxicities of arsenic is a skin lesion. In this study, we tryto elucidate the chronic toxicity of arsenic against neuronal functions, focusing onglutamate receptors, major neurotransmitter receptors in central nervous system.
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