2012 Fiscal Year Final Research Report
Clinico-epidemiological relevance of serum oxygenated B_2-microglobulin
| Project/Area Number |
23659364
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
SHINKAI Shoji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60171063)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Toshifusa 横浜市立大学, 先端医科学研究センター, 教授 (80133635)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血清β2 ミクログロブリン / 分子修飾 / 臨床疫学的意義 / 高齢者 |
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| Research Abstract |
This study aimed to examine the clinico-epidemiologic relevance of serum oxygenated β2-microglobulin (β2-M) found in sera only from older adults. The method for detecting oxygenated β2-M with mass-spectrophotometry was not stable and we finally abandoned further to develop the method. Instead, we examined further the role of serum total β2-M for predicting cardiovascular mortality and found that serum β2-M is a novel risk marker for stroke mortality but not for heart disease mortality in a general population of older adults.
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Research Products
(29 results)
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[Journal Article] Immunoprotective effects of oral intake of heat-killed Lactobacillus Pentosus strain b240 in elderly adults : A randomized, double-blind, placebocontrolled trial.2013
Author(s)
Shinkai S, Toba M, Saito T, Sato I, Tsubouchi M, Taira K, Kakumoto K, Inamatsu T, Yoshida H, Fujiwara Y, Fukaya T, Matsumoto T, Tateda K, Yamaguchi K, Nohda N, Kohno S
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Journal Title
British Journal of Nutrition
Volume: 109
Pages: 1856-1865
DOI
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[Journal Article] 『介護予防チェックリスト』の虚弱指標としての妥当性の検証.2013
Author(s)
新開省二, 渡辺直紀, 吉田裕人, 藤原佳典, 西真理子, 深谷太郎, 李相侖, 金美芝,小川貴志子, 村山洋史, 谷口優, 清水由美子
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Journal Title
日本公衆衛生雑誌
Volume: 60
Pages: 262-274
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[Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals.2011
Author(s)
Horibe H, Kato K, Oguri M, Yoshida T, Fujimaki T, Kawamiya T, Yokoi K, Watanabe S, Satoh K, Aoyagi Y, Tanaka M, Yoshida H, Shinkai S, Nozawa Y, Murohara T, Yamada Y
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Journal Title
Am J Hypertension
Volume: 24
Pages: 924-929
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[Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.2011
Author(s)
Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han B-G, Ahn Y, Lee M, Shin D-J, Lee JH, Jang Y
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Journal Title
Atherosclerosis
Volume: 215
Pages: 145-152
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[Presentation] 草津町における介護予防10年間の歩みと成果(1)ねらいとプロセス評価2012
Author(s)
新開省二, 吉田裕人, 深谷太郎, 藤原佳典, 天野秀紀, 西真理子, 村山洋史, 谷口優,野藤悠, 干川なつみ, 土屋由美子
Organizer
第71回日本公衆衛生学会総会
Place of Presentation
山口
Year and Date
20121024-26
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[Presentation] Frailty Index(虚弱指標)の開発～『介護予防チェックリスト』のFrailty Index(虚弱指標)としての妥当性の検証～2011
Author(s)
新開省二, 渡辺直紀, 吉田裕人, 西真理子, 村山洋史, 天野秀紀, 藤原佳典, 深谷太郎, 小川貴志子, 金美芝, 李相侖
Organizer
第70回日本公衆衛生学会総会
Place of Presentation
秋田
Year and Date
20111019-21
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